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Cellular communication in the cancer microenvironment

Date:
January 21, 2010
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists lend new insight into the mechanism by which tumor-associated macrophages promote malignant progression.

In the February 1st issue of Genes & Development, Dr. Johanna Joyce and colleagues at Memorial Sloan Kettering Cancer Center lend new insight into the mechanism by which tumor-associated macrophages promote malignant progression.

Innate immune cells, including macrophages, comprise a large fraction of the cellular environment that infiltrates tumors -- the so-called "tumor microenvironment." Tumors have a dynamic relationship with their microenvironment, communicating via secreted factors to modulate cellular growth and cancer progression.

In their upcoming G&D paper, Dr. Joyce and colleagues delineate how tumor-associated macrophages (TAMs) promote tumor growth and invasion. The researchers found that macrophage cells infiltrating pancreatic, mammary and lung tumors produce high levels of the proteases cathepsin B and S (Cts B and S), which enhances tumor growth and invasion. Interestingly, the researchers discovered that increased Cts B and S activity is stimulated by the tumors, themselves -- through the release of interleukin (IL)-4.

The study is highly anticipated because it provides novel and compelling evidence for the therapeutic targeting of the tumor microenvironment -- specifically TAMs -- to disrupt communication and ultimately impede cancer progression.

Dr. Joyce is optimistic that "the identification of factors that are differentially produced by conscripted cells in the tumor microenvironment provides a strategy to selectively target these cells in combination with targeting the cancer cells, an approach that could have significant therapeutic potential."


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Cellular communication in the cancer microenvironment." ScienceDaily. ScienceDaily, 21 January 2010. <www.sciencedaily.com/releases/2010/01/100115182625.htm>.
Cold Spring Harbor Laboratory. (2010, January 21). Cellular communication in the cancer microenvironment. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/01/100115182625.htm
Cold Spring Harbor Laboratory. "Cellular communication in the cancer microenvironment." ScienceDaily. www.sciencedaily.com/releases/2010/01/100115182625.htm (accessed July 28, 2014).

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