Featured Research

from universities, journals, and other organizations

Cellular communication in the cancer microenvironment

Date:
January 21, 2010
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists lend new insight into the mechanism by which tumor-associated macrophages promote malignant progression.

In the February 1st issue of Genes & Development, Dr. Johanna Joyce and colleagues at Memorial Sloan Kettering Cancer Center lend new insight into the mechanism by which tumor-associated macrophages promote malignant progression.

Related Articles


Innate immune cells, including macrophages, comprise a large fraction of the cellular environment that infiltrates tumors -- the so-called "tumor microenvironment." Tumors have a dynamic relationship with their microenvironment, communicating via secreted factors to modulate cellular growth and cancer progression.

In their upcoming G&D paper, Dr. Joyce and colleagues delineate how tumor-associated macrophages (TAMs) promote tumor growth and invasion. The researchers found that macrophage cells infiltrating pancreatic, mammary and lung tumors produce high levels of the proteases cathepsin B and S (Cts B and S), which enhances tumor growth and invasion. Interestingly, the researchers discovered that increased Cts B and S activity is stimulated by the tumors, themselves -- through the release of interleukin (IL)-4.

The study is highly anticipated because it provides novel and compelling evidence for the therapeutic targeting of the tumor microenvironment -- specifically TAMs -- to disrupt communication and ultimately impede cancer progression.

Dr. Joyce is optimistic that "the identification of factors that are differentially produced by conscripted cells in the tumor microenvironment provides a strategy to selectively target these cells in combination with targeting the cancer cells, an approach that could have significant therapeutic potential."


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Cellular communication in the cancer microenvironment." ScienceDaily. ScienceDaily, 21 January 2010. <www.sciencedaily.com/releases/2010/01/100115182625.htm>.
Cold Spring Harbor Laboratory. (2010, January 21). Cellular communication in the cancer microenvironment. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/01/100115182625.htm
Cold Spring Harbor Laboratory. "Cellular communication in the cancer microenvironment." ScienceDaily. www.sciencedaily.com/releases/2010/01/100115182625.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins