Featured Research

from universities, journals, and other organizations

Link examined between omega-3 fatty acid levels and biological aging marker in patients with coronary heart disease

Date:
January 22, 2010
Source:
JAMA and Archives Journals
Summary:
Patients with coronary heart disease who had higher omega-3 fatty acid blood levels had an associated lower rate of shortening of telomere length, a chromosome marker of biological aging, raising the possibility that these fatty acids may protect against cellular aging, according to a new study.

Patients with coronary heart disease who had higher omega-3 fatty acid blood levels had an associated lower rate of shortening of telomere length, a chromosome marker of biological aging, raising the possibility that these fatty acids may protect against cellular aging, according to a study in the January 20 issue of JAMA.

Related Articles


Several studies have shown increased survival rates among individuals with high dietary intake of marine omega-3 fatty acids and established cardiovascular disease. The mechanisms underlying this protective effect are not well understood, according to background information in the article.

Telomeres are a structure at the end of a chromosome involved in the replication and stability of the chromosome. Genetic factors and environmental stressors can shorten the length of the telomere, with telomere length becoming an emerging marker of biological age.

Ramin Farzaneh-Far, M.D., of the University of California, San Francisco, and colleagues conducted a study to determine whether omega-3 fatty acid blood levels were associated with changes in leukocyte (a type of blood cell) telomere length in a study of 608 outpatients with stable coronary artery disease. The patients were recruited between September 2000 and December 2002 for the Heart and Soul Study, and followed up to January 2009 (median [midpoint], 6.0 years). The researchers measured leukocyte telomere length at the beginning of the study and again after 5 years of follow-up. Multivariable models were used to examine the association of baseline levels of omega-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) with subsequent change in telomere length.

The researchers found that individuals in the lowest quartile of DHA+EPA experienced the most rapid rate of telomere shortening, whereas those in the highest quartile experienced the slowest rate of telomere shortening. "Levels of DHA+EPA were associated with less telomere shortening before and after sequential adjustment for established risk factors and potential confounders. Each 1-standard deviation increase in DHA+EPA levels was associated with a 32 percent reduction in the odds of telomere shortening," the authors write.

"In summary, among patients with stable coronary artery disease, there was an inverse relationship between baseline blood levels of marine omega-3 fatty acids and the rate of telomere shortening over 5 years."

"These findings raise the possibility that omega-3 fatty acids may protect against cellular aging in patients with coronary heart disease," the researchers write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ramin Farzaneh-Far; Jue Lin; Elissa S. Epel; William S. Harris; Elizabeth H. Blackburn; Mary A. Whooley. Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease. JAMA, 2010; 303 (3): 250-257 [link]

Cite This Page:

JAMA and Archives Journals. "Link examined between omega-3 fatty acid levels and biological aging marker in patients with coronary heart disease." ScienceDaily. ScienceDaily, 22 January 2010. <www.sciencedaily.com/releases/2010/01/100119161758.htm>.
JAMA and Archives Journals. (2010, January 22). Link examined between omega-3 fatty acid levels and biological aging marker in patients with coronary heart disease. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/01/100119161758.htm
JAMA and Archives Journals. "Link examined between omega-3 fatty acid levels and biological aging marker in patients with coronary heart disease." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119161758.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins