Featured Research

from universities, journals, and other organizations

New vaccine could be lethal weapon against malaria, cholera

Date:
January 27, 2010
Source:
University of Central Florida
Summary:
Mankind may finally have a weapon to fight two of the world's deadliest diseases. A biomedical researcher has developed what promises to be the first low-cost dual vaccine against malaria and cholera.

Henry Daniell of University of Central Florida works developing "green vaccines."
Credit: Jacque Brund/UCF

Mankind may finally have a weapon to fight two of the world's deadliest diseases.

Related Articles


A University of Central Florida biomedical researcher has developed what promises to be the first low-cost dual vaccine against malaria and cholera.

There is no FDA approved vaccine to prevent malaria, a mosquito-borne illness that kills more than 1 million people annually. Only one vaccine exists to fight cholera, a diarrheal illness that is common in developing countries and can be fatal. The lone vaccine is too expensive to prevent outbreaks in developing countries after floods, and children lose immunity within three years of getting the current vaccine.

"I'm very encouraged because our technique works well and provides an affordable way to get vaccines to people who need them most and can least afford them," said lead scientist Henry Daniell.

Daniell's team genetically engineered tobacco and lettuce plants to produce the vaccine. Researchers gave mice freeze-dried plant cells (orally or by injection) containing the vaccine. They then challenged the mice with either the cholera toxin or malarial parasite. The malaria parasite studies were completed in fellow UCF professor Debopam Chakrabarti's lab.

Untreated rodents contracted diseases quickly, but the mice who received the plant-grown vaccines showed long-lasting immunity for more than 300 days (equivalent to 50 human years).

Results from the National Institutes of Health-funded research are published in this month's Plant Biotechnology, the top-ranked journal in the field.

Clinical trials are needed, and Daniell is hopeful that the results with mice will translate to humans. It could be yet another example of plants delivering life-saving medicines.

The dual vaccine follows a string of other "green" vaccines developed in Daniell's lab. He's created vaccines against anthrax and black plague that generated a congratulatory call from the top U.S. homeland security official and was featured on the Discovery Channel. He's also successfully grown insulin in plants to find what could be a long-lasting cure for diabetes. Daniell's team continues to research these vaccines and is looking for investors to help fund clinical trials.

Producing vaccines in plants is less expensive than traditional methods because it requires less labor and technology, Daniell said.

"We're talking about producing mass quantities for pennies on the dollar," he said. "And distribution to mass populations would be easy because it could be made into a simple pill, like a vitamin, which many people routinely take now. There is no need for expensive purification, cold storage, transportation or sterile delivery via injections."

For Daniell, his research is more than his day job. His passion to find vaccines for the world's top 10 diseases as defined by the World Health Organization comes from growing up in India. He watched many of his childhood friends contract malaria, cholera and other diseases.

Daniell, a father of two, joined UCF's Burnett School of Biomedical Sciences in the College of Medicine in 1998. His research led to the formation of the university's first biotechnology company. Daniell also became only the 14th American in the last 222 years to be elected the Italian National Academy of Sciences. In 2007 he was named a Fellow of the American Association for the Advancement of Sciences.

"I'm not done yet," he said. "I still have more diseases to attack."

Other researchers working on the dual vaccine project include Abdoreza Davoodi-Semiromi, Melissa Schreiber, Samson Nallapali, Dheeraj Verma, Nameirakpam D. Singh and Robert K. Banks.


Story Source:

The above story is based on materials provided by University of Central Florida. Note: Materials may be edited for content and length.


Cite This Page:

University of Central Florida. "New vaccine could be lethal weapon against malaria, cholera." ScienceDaily. ScienceDaily, 27 January 2010. <www.sciencedaily.com/releases/2010/01/100126101421.htm>.
University of Central Florida. (2010, January 27). New vaccine could be lethal weapon against malaria, cholera. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/01/100126101421.htm
University of Central Florida. "New vaccine could be lethal weapon against malaria, cholera." ScienceDaily. www.sciencedaily.com/releases/2010/01/100126101421.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins