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Antibodies attack immune proteins

Date:
February 1, 2010
Source:
Rockefeller University Press
Summary:
Two new studies reveal that patients with a rare autoimmune disease produce antibodies that attack microbe-fighting immune proteins called cytokines. These findings may help explain why these patients suffer recurrent yeast infections.

Two studies published online on February 1 in the Journal of Experimental Medicine reveal that patients with a rare autoimmune disease produce antibodies that attack microbe-fighting immune proteins called cytokines. These findings may help explain why these patients suffer recurrent yeast infections.

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Autoimmune polyendocrine syndrome, or APS-I, afflicts one in 100,000 people and is characterized by disrupted thyroid and adrenal gland function and recurrent skin infections with one type of yeast. Normally, the immune system produces cytokines that help protect the body against airborne yeast and other environmental pathogens.

Two teams of researchers -- one led by Anthony Meager at the National Institute for Biological Standards and Control (UK), and the other led by Desa Lilic at Newcastle University (UK) and Jean-Laurent Casanova at Rockefeller University (New York) -- found that patients with APS-I produce autoantibodies that bind to and disarm these yeast-fighting cytokines.

It is not yet clear why these patients are prone to infection with only one type of yeast. But these studies suggest that cytokine replacement therapy might be considered in the treatment of APS-I patients.

Kisand, K., et al. 2010. J. Exp. Med. doi:10.1084/jem.20091669.

Puel, A., et al. 2010. J. Exp. Med. doi:10.1084/jem.20091983.


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The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


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Rockefeller University Press. "Antibodies attack immune proteins." ScienceDaily. ScienceDaily, 1 February 2010. <www.sciencedaily.com/releases/2010/02/100201093033.htm>.
Rockefeller University Press. (2010, February 1). Antibodies attack immune proteins. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2010/02/100201093033.htm
Rockefeller University Press. "Antibodies attack immune proteins." ScienceDaily. www.sciencedaily.com/releases/2010/02/100201093033.htm (accessed January 26, 2015).

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