Featured Research

from universities, journals, and other organizations

Discovery may expand availability of bone marrow transplants by stopping fatal complications

Date:
February 8, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
Scientists explain how an anti-inflammatory agent called "ATL146e" may significantly improve the likelihood of success for bone marrow transplants by preventing or halting the progression of graft-versus-host disease, a complication of bone marrow transplants in which the donor marrow attacks the host.

If a team of American scientists are right, bone marrow transplants may become safer and more available to people in need of donations. In a new research paper appearing in the February 2010 print edition of the Journal of Leukocyte Biology, they explain how an anti-inflammatory agent called "ATL146e" may significantly improve the likelihood of success for bone marrow transplants by preventing or halting the progression of graft-versus-host disease, a complication of bone marrow transplants in which the donor marrow attacks the host.

Although very rare, graft-versus-host disease can also occur after blood transfusions.

"We hope that this study is the first step in the development and implementation of a new treatment for graft-versus-host disease," said Courtney M. Lappas, Ph.D., one of the scientists involved in the study. "This is important clinically because it could potentially minimize the risks associated with bone marrow transplantation, making these potentially curative transplants safer and more widely used in individuals with inherited immunodeficiency diseases."

Scientists performed bone marrow transplants using two genetically different strains of mice, causing graft-versus-host disease in the recipients. Some of recipient mice were then treated with ATL146e and others were given a placebo. In mice treated before the disease took hold, the severity of graft-versus-host disease was reduced, leading to a significant decrease in tissue damage and an increase in survival. In mice that already had graft-versus-host disease, treatment with ATL146e reversed the disease.

"Bone marrow transplants have saved thousands of lives, but for some this lifesaving therapy can become fatal," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This research is very exciting because ultimately, it might improve the safety of bone marrow transplants and perhaps even open up new opportunities for this therapy in other diseases."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lappas et al. Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation. Journal of Leukocyte Biology, 2010; 87 (2): 345 DOI: 10.1189/jlb.0609388

Cite This Page:

Federation of American Societies for Experimental Biology. "Discovery may expand availability of bone marrow transplants by stopping fatal complications." ScienceDaily. ScienceDaily, 8 February 2010. <www.sciencedaily.com/releases/2010/02/100201101909.htm>.
Federation of American Societies for Experimental Biology. (2010, February 8). Discovery may expand availability of bone marrow transplants by stopping fatal complications. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/02/100201101909.htm
Federation of American Societies for Experimental Biology. "Discovery may expand availability of bone marrow transplants by stopping fatal complications." ScienceDaily. www.sciencedaily.com/releases/2010/02/100201101909.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins