Featured Research

from universities, journals, and other organizations

Discovery may expand availability of bone marrow transplants by stopping fatal complications

Date:
February 8, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
Scientists explain how an anti-inflammatory agent called "ATL146e" may significantly improve the likelihood of success for bone marrow transplants by preventing or halting the progression of graft-versus-host disease, a complication of bone marrow transplants in which the donor marrow attacks the host.

If a team of American scientists are right, bone marrow transplants may become safer and more available to people in need of donations. In a new research paper appearing in the February 2010 print edition of the Journal of Leukocyte Biology, they explain how an anti-inflammatory agent called "ATL146e" may significantly improve the likelihood of success for bone marrow transplants by preventing or halting the progression of graft-versus-host disease, a complication of bone marrow transplants in which the donor marrow attacks the host.

Related Articles


Although very rare, graft-versus-host disease can also occur after blood transfusions.

"We hope that this study is the first step in the development and implementation of a new treatment for graft-versus-host disease," said Courtney M. Lappas, Ph.D., one of the scientists involved in the study. "This is important clinically because it could potentially minimize the risks associated with bone marrow transplantation, making these potentially curative transplants safer and more widely used in individuals with inherited immunodeficiency diseases."

Scientists performed bone marrow transplants using two genetically different strains of mice, causing graft-versus-host disease in the recipients. Some of recipient mice were then treated with ATL146e and others were given a placebo. In mice treated before the disease took hold, the severity of graft-versus-host disease was reduced, leading to a significant decrease in tissue damage and an increase in survival. In mice that already had graft-versus-host disease, treatment with ATL146e reversed the disease.

"Bone marrow transplants have saved thousands of lives, but for some this lifesaving therapy can become fatal," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This research is very exciting because ultimately, it might improve the safety of bone marrow transplants and perhaps even open up new opportunities for this therapy in other diseases."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lappas et al. Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation. Journal of Leukocyte Biology, 2010; 87 (2): 345 DOI: 10.1189/jlb.0609388

Cite This Page:

Federation of American Societies for Experimental Biology. "Discovery may expand availability of bone marrow transplants by stopping fatal complications." ScienceDaily. ScienceDaily, 8 February 2010. <www.sciencedaily.com/releases/2010/02/100201101909.htm>.
Federation of American Societies for Experimental Biology. (2010, February 8). Discovery may expand availability of bone marrow transplants by stopping fatal complications. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/02/100201101909.htm
Federation of American Societies for Experimental Biology. "Discovery may expand availability of bone marrow transplants by stopping fatal complications." ScienceDaily. www.sciencedaily.com/releases/2010/02/100201101909.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins