Featured Research

from universities, journals, and other organizations

New way to lose fat, keep the lean

Date:
February 3, 2010
Source:
Cell Press
Summary:
Researchers may have a new way to trick the body into consuming more energy. The target in this case is an enzyme that indirectly controls the activity of what the researchers refer to as the "energy master switch." It boils down to this: When you give mice a chemical that blocks the function of the enzyme known as Fyn kinase, they almost immediately begin burning more fat.

Researchers reporting in the February 3rd issue of Cell Metabolism may have a new way to trick the body into consuming more energy. The target in this case is an enzyme that indirectly controls the activity of what the researchers refer to as the "energy master switch." It boils down to this: When you give mice a chemical that blocks the function of the enzyme known as Fyn kinase, they almost immediately begin burning more fat.

Related Articles


"When there is an imbalance between what we eat and what we burn," the outcome is obesity, said Claire Bastie of the Albert Einstein College of Medicine and Neuroscience. "And the problem of obesity is not going away. This is a new mechanism to help the body to burn extra energy."

Bastie's team earlier showed that mice lacking Fyn kinase altogether burn more fatty acids and expend more energy to become leaner. They also showed other metabolic improvements, including increased insulin sensitivity. Those effects were the result of higher levels of the master energy switch AMPK in their fat and muscle tissue.

Those findings suggested that the enzyme might offer a useful target for a new kind of weight loss drug. Now, the researchers add support for that idea by showing that chemical inhibition of Fyn kinase with an experimental drug known only as SU6656 does have considerable metabolic benefits for mice. Ultimately, the animals appear to become increasingly fit as they lose fat and keep the lean.

The researchers further detailed exactly how the Fyn kinase works its magic. It acts on another component of the energy pathway, which leads to a change in AMPK levels.

Bastie said that SU6656 itself isn't an ideal drug candidate for clinical trials of the approach in humans. That's because Fyn kinase and AMPK both have effects in the brain as well as in fat and muscle. Scientists would need a drug that hits those molecular players only where you wanted it to. "Our next goal is to design something extremely specific to muscle and adipose," Bastie said.

She said she wants to find out what Fyn kinase and AMPK are doing in the brain, where she suspects they may play some role in appetite control. She also wants to find out what normally controls Fyn kinase levels, noting that it may be a fatty acid or some other nutrient.

The researchers include Eijiro Yamada, Jeffrey E. Pessin, Irwin J. Kurland, Gary J. Schwartz, and Claire C. Bastie, at Albert Einstein College of Medicine, Bronx, NY.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "New way to lose fat, keep the lean." ScienceDaily. ScienceDaily, 3 February 2010. <www.sciencedaily.com/releases/2010/02/100202120804.htm>.
Cell Press. (2010, February 3). New way to lose fat, keep the lean. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2010/02/100202120804.htm
Cell Press. "New way to lose fat, keep the lean." ScienceDaily. www.sciencedaily.com/releases/2010/02/100202120804.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
Obamacare's New Supreme Court Battle

Obamacare's New Supreme Court Battle

Washington Post (Mar. 4, 2015) The Affordable Care Act is facing another challenge at the Supreme Court in King v. Burwell, which deals with subsidies for health insurance. The case could cut out a major provision of Obamacare, causing the law to unravel. Here’s what you need to know about the case. Video provided by Washington Post
Powered by NewsLook.com
Investigation Finds Hurt Workers Suffer More In Some States

Investigation Finds Hurt Workers Suffer More In Some States

Newsy (Mar. 4, 2015) ProPublica and NPR&apos;s joint investigation found drastic cuts to workers compensation benefits and employees&apos; access to those benefits. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins