Featured Research

from universities, journals, and other organizations

Screening for spinal muscular atrophy not cost effective, study finds

Date:
February 8, 2010
Source:
Society for Maternal-Fetal Medicine
Summary:
New findings suggest that it is not cost effective to screen for spinal muscular atrophy. Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality and the second most common inherited autosomal recessive disorder. There is controversy about whether prenatal carrier detection should be routinely offered to couples.

In a study to be presented at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting ™, in Chicago, researchers will unveil findings that show that it is not cost effective to screen for spinal muscular atrophy.

Related Articles


Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality and the second most common inherited autosomal recessive disorder. There is controversy about whether prenatal carrier detection should be routinely offered to couples. In the November 2008 issue of the Genetics in Medicine Journal, the American College of Medical Genetics recommended that carrier screening for SMA should be made available to all families. However, the American College of Obstetricians and Gynecologists, in a committee opinion from May 2009, recommended against preconception and prenatal screening in the general population.

In the study presented at the Society for Maternal-Fetal Medicine's meeting, researchers describe the analytic model that was created to compare a policy of universal prenatal SMA screening to that of no screening. Baseline assumptions included a disease prevalence of 1 in 10,000 for a carrier rate of 1 in 50 with 70% of affected children having severe disease. They assumed a 90% sensitivity rate for carrier screening and that 2% of SMA cases arise from de novo mutations. Baseline cost estimates (2009 dollars) included $400 for a carrier screen and $260,000 for the lifetime cost of a child with severe disease. Maternal quality-adjusted life-years (QALYs) were calculated assuming a 22% reduction in quality of life for having a child with severe disease and 8% for fetal loss.

The results showed that 11,000 women would have to be screened to prevent one case of SMA, at a cost of 4.7 million dollars per case averted.

"Our findings show that screening everyone for SMA is not cost effective," said one of the study's authors, Dr. Sarah Little of Massachusetts General Hospital. "Our results, however, were most sensitive to changes in the baseline prevalence of disease, suggesting that prenatal SMA screening may be cost effective in high risk populations, such as those with a family history of disease."


Story Source:

The above story is based on materials provided by Society for Maternal-Fetal Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society for Maternal-Fetal Medicine. "Screening for spinal muscular atrophy not cost effective, study finds." ScienceDaily. ScienceDaily, 8 February 2010. <www.sciencedaily.com/releases/2010/02/100205081807.htm>.
Society for Maternal-Fetal Medicine. (2010, February 8). Screening for spinal muscular atrophy not cost effective, study finds. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/02/100205081807.htm
Society for Maternal-Fetal Medicine. "Screening for spinal muscular atrophy not cost effective, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/02/100205081807.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins