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Gastrointestinal absorption of Tamiflu in critically ill patients with H1N1

Date:
February 16, 2010
Source:
Canadian Medical Association Journal
Summary:
An increased dosage of Tamiflu for patients with critical illness is unlikely to be required in the treatment of pandemic (H1N1) influenza, contrary to current international guidelines.

An increased dosage of Tamiflu (oseltamivir) for patients with critical illness is unlikely to be required in the treatment of pandemic (H1N1) influenza, contrary to current international guidelines, found a new study in CMAJ (Canadian Medical Association Journal).

World Health Organization (WHO) guidelines recommend that all critically ill patients should be treated with Tamiflu and if the patient was unresponsive to standard doses or critically ill, a higher dose should be considered.

The CMAJ study looked at the gastrointestinal absorption of Tamiflu in 44 patients, 18 years of age or older, with suspected or confirmed pandemic (H1N1) influenza who were admitted to nine ICUs in two cities in Canada (Winnipeg and Ottawa) and Tarragona, Spain because of respiratory failure. As critically ill patients may have gastrointestinal absorption issues, guidelines suggest higher doses of Tamiflu.

"Studying the absorption ability of Tamiflu in the critically ill became a priority with the large number of patients needing ICU and ventilation support," writes lead author Dr. Anand Kumar, Health Sciences Centre, University of Manitoba and coauthors. "Also, the number of obese patients suffering from H1N1 related critical illnesses were large which raised the question about whether the dose should be adjusted upwards with increased body weight."

Blood sampling indicated that the 75 mg twice daily dosage of Tamiflu was well absorbed in critically ill patients with respiratory failure. Blood levels of the antiviral were similar or higher than levels in ambulatory patients with a similar dosage. Patients with kidney dysfunction requiring dialysis needed an adjusted dose but adjustment for obesity was not required.

"The findings of this study suggest that an increased Tamiflu dosage is unlikely to be necessary in such cases based on either insufficient drug absorption or altered distribution pharmacokinetics," conclude the authors.


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert E Ariano, Daniel S Sitar, Sheryl A Zelenitsky, Ryan Zarychanski, Amarnath Pisipati, Stιphane Ahern, Salmaan Kanji, Jordi Rello, Anand Kumar. Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza. CMAJ, February 16, 2010 DOI: 10.1503/cmaj.092127

Cite This Page:

Canadian Medical Association Journal. "Gastrointestinal absorption of Tamiflu in critically ill patients with H1N1." ScienceDaily. ScienceDaily, 16 February 2010. <www.sciencedaily.com/releases/2010/02/100216113901.htm>.
Canadian Medical Association Journal. (2010, February 16). Gastrointestinal absorption of Tamiflu in critically ill patients with H1N1. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/02/100216113901.htm
Canadian Medical Association Journal. "Gastrointestinal absorption of Tamiflu in critically ill patients with H1N1." ScienceDaily. www.sciencedaily.com/releases/2010/02/100216113901.htm (accessed October 23, 2014).

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