Featured Research

from universities, journals, and other organizations

Researchers identify a potential therapeutic target for brain cancer

Date:
February 23, 2010
Source:
Public Library of Science
Summary:
Researchers report the identification of a protein that is highly expressed in a subgroup of glioblastoma brain tumor cells and show that depletion of this protein increases the survival of mice with these tumors.

Researchers at the Cleveland Clinic report the identification of a protein that is highly expressed in a subgroup of glioblastoma brain tumor cells and show that depletion of this protein increases the survival of mice with these tumors. This work will be published in the online open-access journal PLoS Biology.

Related Articles


Recent studies have increased our understanding of cancer by elucidating some of the differences that exist between tumor cells among patients and even between distinct subsets of tumor cells within the same patient. Evidence suggests there are subgroups of cells -- called cancer stem cells or tumor initiating cells -- within tumors that are harder to kill with current therapies than other cells within these tumors. Cancer stem cells may in fact be more important to destroy than non-cancer stem cells because they may be responsible for metastasis and for tumor recurrence after therapy. Identifying therapies which specifically target cancer stem cells therefore hold great promise for effective and lasting treatment.

In this study, Dr. Hjelmeland and colleagues determine that a protein called A20, that has been previously implicated in cell survival, is highly expressed in a population of cells that is enriched for glioblastoma stem cells. They demonstrate that decreasing levels of A20 in these cells reduces their growth in cell culture by inducing cell death. Decreasing A20 levels in animal models of brain tumors also increases survival. Using publicly available datasets from human brain tumor specimens, they also determine that increased levels of A20 are associated with poor patient survival. Together, these studies suggest that targeting A20 could be beneficial for human glioblastoma patients.

Although there continues to be controversy over the cancer stem cell concept, Dr. Hjelmeland believes that "Everyone recognizes the need to identify new cancer targets, and this may be achieved by studying subgroups of tumor cells. Using this technique, we identified A20 as an important target. However, we still have a lot of work to do before translation for patient therapies."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hjelmeland AB, Wu Q, Wickman S, Eyler C, Heddleston J, et al. Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. PLoS Biology, 2010; 8 (2): e1000319 DOI: 10.1371/journal.pbio.1000319

Cite This Page:

Public Library of Science. "Researchers identify a potential therapeutic target for brain cancer." ScienceDaily. ScienceDaily, 23 February 2010. <www.sciencedaily.com/releases/2010/02/100222200851.htm>.
Public Library of Science. (2010, February 23). Researchers identify a potential therapeutic target for brain cancer. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2010/02/100222200851.htm
Public Library of Science. "Researchers identify a potential therapeutic target for brain cancer." ScienceDaily. www.sciencedaily.com/releases/2010/02/100222200851.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins