Featured Research

from universities, journals, and other organizations

Drug delivery breakthrough: Vehicle that can carry drugs to a specific organelle inside the cell

Date:
February 25, 2010
Source:
University of Greenwich
Summary:
A team of scientists has got a step closer to one of the holy grails of drug delivery. The goal -- to find a vehicle that can carry drugs not just to a specific cell but a specific organ (organelle) inside the cell, and accurately measure how it behaves when it gets there -- has proved elusive despite two decades of research.

A team of scientists led by Dr Simon Richardson at the University of Greenwich has got a step closer to one of the holy grails of drug delivery.

Related Articles


The goal -- to find a vehicle that can carry drugs not just to a specific cell but a specific organ (organelle) inside the cell, and accurately measure how it behaves when it gets there -- has proved elusive despite two decades of research, according to the Journal of Controlled Release, a top international scientific publication.

Now the journal has given the new research front page billing, saying in an editorial that Richardson and colleagues provide direct evidence, for the first time, that nanomedicines can be delivered to select organelles and manipulated to carry beneficial agents like genes.

Dr Richardson says: "Drug delivery is important for everyone because it has the potential to deliver new treatments for diseases which are currently incurable; and to deliver existing drugs more effectively."

"We are trying to smuggle healthy genes inside cells. Genes are large molecules which have up till now proved too big to get in without serious risk to the patient. Our research is at the cutting edge of efforts to turn gene therapy, and new molecular medicines, from risky and sci-fiesque to safe and routine."

As well as proving that material like genes can be delivered to the target organelle, the team was also able to show how the delivery vehicle behaves once inside.

Editor of the Journal of Controlled Release, Professor Kinam Park, said the study was "distinguished from others by its thoroughness and unequivocal data" and concludes: "…the approach used by Richardson's team can be useful in developing more efficient delivery vehicles for drug targeting in general."


Story Source:

The above story is based on materials provided by University of Greenwich. Note: Materials may be edited for content and length.


Journal Reference:

  1. S.C.W. Richardson, N.G. Pattrick, N. Lavignac, P. Ferruti, R. Duncan. Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo. Journal of Controlled Release, 2010; 142 (1): 78 DOI: 10.1016/j.jconrel.2009.09.025

Cite This Page:

University of Greenwich. "Drug delivery breakthrough: Vehicle that can carry drugs to a specific organelle inside the cell." ScienceDaily. ScienceDaily, 25 February 2010. <www.sciencedaily.com/releases/2010/02/100224134327.htm>.
University of Greenwich. (2010, February 25). Drug delivery breakthrough: Vehicle that can carry drugs to a specific organelle inside the cell. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2010/02/100224134327.htm
University of Greenwich. "Drug delivery breakthrough: Vehicle that can carry drugs to a specific organelle inside the cell." ScienceDaily. www.sciencedaily.com/releases/2010/02/100224134327.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins