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Pinpointing immune system disturbances in celiac disease

Date:
March 1, 2010
Source:
Queen Mary, University of London
Summary:
New research has identified four aspects of immune system disturbance which lead to the development of celiac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified. These latest findings could speed the way towards improved diagnostics and treatments for the autoimmune complaint that affects 1 in 100 of the population, and lead to insights into related conditions such as type 1 diabetes.

New research has identified four aspects of immune system disturbance which lead to the development of coeliac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified. These latest findings could speed the way towards improved diagnostics and treatments for the autoimmune complaint that affects 1 in 100 of the population, and lead to insights into related conditions such as type 1 diabetes.

David van Heel, Professor of Gastrointestinal Genetics at Barts and The London School of Medicine and Dentistry has led an international team of researchers towards the discovery. Results of their research, funded by the Wellcome Trust, and supported by the patient charity Coeliac UK, are published online in Nature Genetics on Feb. 28, 2010.

Professor van Heel, commenting on the latest findings said: "We can now shed light on some of the precise immune disturbances leading to coeliac disease. These include how T cells in the body react to toxic wheat proteins, how the thymus gland eliminates these T cells during infancy, and the body's response to viral infections. We now understand that many of these genetic risk factors work by altering the amounts of these immune system genes that cells make. The data also suggests that coeliac disease is made up of hundreds of genetic risk factors, we can have a good guess at nearly half of the genetic risk at present."

The study also shows that there is substantial evidence to indicate a shared risk between the gene associated with coeliac disease and many other common chronic immune mediated diseases. Previously Professor van Heel had identified an overlap between coeliac disease and type 1 diabetes risk regions, as well as coeliac disease and rheumatoid arthritis.

Coeliac disease is common in the West, affecting around one per cent of the population. It is an auto-immune disease triggered by an intolerance to gluten (a protein found in foods containing wheat, barley and rye) that prevents normal absorption of nutrients. If undetected it can lead to severe health problems including anaemia, poor bone health, fatigue and weight loss.


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dubois et al. Multiple common variants for celiac disease influencing immune gene expression. Nature Genetics, 2010; DOI: 10.1038/ng.543

Cite This Page:

Queen Mary, University of London. "Pinpointing immune system disturbances in celiac disease." ScienceDaily. ScienceDaily, 1 March 2010. <www.sciencedaily.com/releases/2010/02/100228131337.htm>.
Queen Mary, University of London. (2010, March 1). Pinpointing immune system disturbances in celiac disease. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/02/100228131337.htm
Queen Mary, University of London. "Pinpointing immune system disturbances in celiac disease." ScienceDaily. www.sciencedaily.com/releases/2010/02/100228131337.htm (accessed July 28, 2014).

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