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Staying alive: Insufficient vitamin C causes perinatal lethality in mice

Date:
March 1, 2010
Source:
Journal of Clinical Investigation
Summary:
Vitamin C is indispensible for life. We obtain all our vitamin C from out diet and several tightly regulated processes control our vitamin C levels. One protein involved in this is Slc23a1, but its in vivo importance has not been determined. However, researchers have now identified several crucial functions for Slc23a1 in mice: it is involved in absorption of vitamin C by the kidney and in perinatal survival.
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Vitamin C is indispensible for life: without it, an individual develops the fatal disease scurvy. We obtain all our vitamin C from out diet and several tightly regulated processes control the level of vitamin C in our bodies. One protein known to be involved in controlling vitamin C levels is Slc23a1, but the in vivo importance of this has not been determined.

However, Mark Levine and colleagues, at the NIH, Bethesda, have now identified several crucial functions for Slc23a1 in mice. For example, Slc23a1 had a key role in absorption of vitamin C by the kidney and in perinatal survival.

Although the data on perinatal survival are provocative, the authors warn that appropriate clinical data need to be collected before it can be determined whether low levels of vitamin C in women who are pregnant contribute to either perinatal morbidity or mortality.

The research appears in the Journal of Clinical Investigation.


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The above post is reprinted from materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. christopher P. Corpe, Hongbin Tu, Peter Eck, Jin Wang, Robert Faulhaber-Walter, Jurgen Schnermann, Sam Margolis, Sebastian Padayatty, He Sun, Yaohui Wang, Robert L. Nussbaum, Michael Graham Espey and Mark Levine. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI39191

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Journal of Clinical Investigation. "Staying alive: Insufficient vitamin C causes perinatal lethality in mice." ScienceDaily. ScienceDaily, 1 March 2010. <www.sciencedaily.com/releases/2010/03/100301173818.htm>.
Journal of Clinical Investigation. (2010, March 1). Staying alive: Insufficient vitamin C causes perinatal lethality in mice. ScienceDaily. Retrieved September 1, 2015 from www.sciencedaily.com/releases/2010/03/100301173818.htm
Journal of Clinical Investigation. "Staying alive: Insufficient vitamin C causes perinatal lethality in mice." ScienceDaily. www.sciencedaily.com/releases/2010/03/100301173818.htm (accessed September 1, 2015).

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