Featured Research

from universities, journals, and other organizations

Staying alive: Insufficient vitamin C causes perinatal lethality in mice

Date:
March 1, 2010
Source:
Journal of Clinical Investigation
Summary:
Vitamin C is indispensible for life. We obtain all our vitamin C from out diet and several tightly regulated processes control our vitamin C levels. One protein involved in this is Slc23a1, but its in vivo importance has not been determined. However, researchers have now identified several crucial functions for Slc23a1 in mice: it is involved in absorption of vitamin C by the kidney and in perinatal survival.

Vitamin C is indispensible for life: without it, an individual develops the fatal disease scurvy. We obtain all our vitamin C from out diet and several tightly regulated processes control the level of vitamin C in our bodies. One protein known to be involved in controlling vitamin C levels is Slc23a1, but the in vivo importance of this has not been determined.

Related Articles


However, Mark Levine and colleagues, at the NIH, Bethesda, have now identified several crucial functions for Slc23a1 in mice. For example, Slc23a1 had a key role in absorption of vitamin C by the kidney and in perinatal survival.

Although the data on perinatal survival are provocative, the authors warn that appropriate clinical data need to be collected before it can be determined whether low levels of vitamin C in women who are pregnant contribute to either perinatal morbidity or mortality.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. christopher P. Corpe, Hongbin Tu, Peter Eck, Jin Wang, Robert Faulhaber-Walter, Jurgen Schnermann, Sam Margolis, Sebastian Padayatty, He Sun, Yaohui Wang, Robert L. Nussbaum, Michael Graham Espey and Mark Levine. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI39191

Cite This Page:

Journal of Clinical Investigation. "Staying alive: Insufficient vitamin C causes perinatal lethality in mice." ScienceDaily. ScienceDaily, 1 March 2010. <www.sciencedaily.com/releases/2010/03/100301173818.htm>.
Journal of Clinical Investigation. (2010, March 1). Staying alive: Insufficient vitamin C causes perinatal lethality in mice. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2010/03/100301173818.htm
Journal of Clinical Investigation. "Staying alive: Insufficient vitamin C causes perinatal lethality in mice." ScienceDaily. www.sciencedaily.com/releases/2010/03/100301173818.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins