Featured Research

from universities, journals, and other organizations

Hormone replacement therapy linked to increased lung cancer risk

Date:
March 4, 2010
Source:
Oregon Health & Science University
Summary:
Peri- and postmenopausal women aged 50 to 76 who take estrogen plus progestin may have an increased risk of lung cancer.

Women aged 50 to 76 who take estrogen plus progestin may have an increased risk of lung cancer, according to a new study published in the pre-print online edition of the Journal of Clinical Oncology.

Related Articles


Although the risk is "duration-dependent," with women taking HRT for 10-plus years at greatest risk of developing lung cancer, an acceptable length of HRT has yet to be determined, the researchers report.

While the risk of developing lung cancer for women using estrogen plus progestin HRT 10 years or longer was approximately 50 percent more than women not using HRT, this risk is actually quite small compared to the risk from smoking.

"Although HRT use has declined and is not recommended except for short-term treatment of menopausal symptoms, our results indicate millions of women may remain at risk of developing lung cancer," said Chris Slatore, M.D., principal investigator and an assistant professor of medicine (pulmonary and critical care medicine) in the Oregon Health & Science University School of Medicine, Portland Veterans Affairs Medical Center; and a member of the OHSU Knight Cancer Institute.

To conduct this research, Slatore and colleagues reviewed data collected from 2000 to 2002 in the Vitamins and Lifestyle Study in Washington state. They identified 36,588 peri- and postmenopausal participants aged 50 to 76 who met their study criteria and followed them for six years using the Seattle-Puget Sound Surveillance, Epidemiology and End Results cancer registry.

At the end of the observation period, December 31, 2007, 344 of the participants had developed lung cancer. After adjusting for smoking, age and other factors that affect the risk of lung cancer, the researchers determined the use of estrogen and progestin for 10 or more years was associated with increased risk for lung cancer compared with no use of HRT. They also found duration of use was associated with an advanced stage of cancer at diagnosis.

Although the mechanisms underlying the association between HRT and lung cancer are still unknown, the researchers report that genetic and environment interactions likely play a role. They also suggest that estrogen plus progestin may lead to more aggressive disease or mask early symptoms, or HRT users may be less likely to see or receive medical care in a timely fashion.

"These findings may be useful in counseling women about their risk of developing lung cancer and prompt further research into the mechanisms underlying HRT and increased lung cancer risk," said Slatore.

Other researchers who contributed to the study include: Jason W. Chien, M.D., Seattle Cancer Care Alliance; David H. Au, M.D., VA Puget Sound Health Care System; Jessie A. Satia, Ph.D., University of North Carolina; and Emily White, Ph.D., University of Washington.

The study was supported by the CHEST Foundation of the American College of Chest Physicians and the LUNGevity Foundation to C.G.S; the National Institutes of Health; the Department of Veterans Affairs; Portland Veterans Affairs Medical Center, Portland, Ore.; and Veterans Affairs Puget Sound Health Care System, Seattle, Wash.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Hormone replacement therapy linked to increased lung cancer risk." ScienceDaily. ScienceDaily, 4 March 2010. <www.sciencedaily.com/releases/2010/03/100303162928.htm>.
Oregon Health & Science University. (2010, March 4). Hormone replacement therapy linked to increased lung cancer risk. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2010/03/100303162928.htm
Oregon Health & Science University. "Hormone replacement therapy linked to increased lung cancer risk." ScienceDaily. www.sciencedaily.com/releases/2010/03/100303162928.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins