Featured Research

from universities, journals, and other organizations

Stem cell networks in zebrafish

Date:
March 19, 2010
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Embryonic stem cells (ES cells) have invaluable potential for regenerative medicine. Scientists are only just beginning to understand the diverse developmental possibilities ("pluripotency") of ES cells. The Pou5f1/Oct4 protein is one of the most important stem cell factors. However, in contrast to Pou5f1/Oct4 itself, little is known about the structure and function of the regulatory network it controls.

Embryonic stem cells (ES cells) have invaluable potential for regenerative medicine. Scientists are only just beginning to understand the diverse developmental possibilities ("pluripotency") of ES cells. The Pou5f1/Oct4 protein is one of the most important stem cell factors. However, in contrast to Pou5f1/Oct4 itself, little is known about the structure and function of the regulatory network it controls.

Related Articles


This network can support pluripotency, but at the same time it can also enable the allocation of embryonic cells to the various main cell lines. Using the zebrafish as an experimental model, a team of systems biologists from the University of Freiburg led by Prof. Dr. Wolfgang Driever and Dr. Daria Onichtchouk from the Faculty of Biology and Prof. Dr. Jens Timmer from the Institute of Physics has successfully implemented a systems biological approach combining embryology, bioinformatics, and mathematical modeling to explain the basic regulatory mechanisms of the early embryonic gene regulation networks. The team cooperated closely with the university's Center for Systems Biology (ZBSA). The results were published on 9 March 2010 in the journal Molecular Systems Biology.

Stem cells have the potential to become one of the essential therapeutic components in biomedicine for curing the degeneration diseases of an aging society. However, the diverse developmental possibilities of embryonic stem cells also present considerable risks: How can we ensure that the cells we create from stem cells are stable and do not lead to tumors? One of the preconditions for preventing this from happening is a better understanding of the successive steps of regulation in the natural differentiation of stem cells into defined tissue in the embryo. This process of differentiation is controlled by complex networks of regulators and signals in a series of successive regulation phases. It is difficult to study these steps in cell cultures and in the mammal embryo because the steps of differentiation often occur asynchronously in temporal succession (cell culture) and the corresponding developmental stages are not easy to access through experimental means (embryo).

The team of system biologists tackled and threw light on important aspects of precisely this regulation network in their study. The decisive step for reaching a more profound understanding of the regulation process consisted in conducting detailed time-resolved analyses of the embryonic transcriptome of wild type embryos and Oct4/Pou5f1-deficient embryos at 10 distinct time points during development. The results of this biological modeling process provide insight not only into the temporal dynamic of the stem cell network, but also into its structure, function, and evolution.

In addition to Prof. Dr. Wolfgang Driever, Dr. Daria Onichtchouk, and Prof. Dr. Jens Timmer, the research team included Dr. Florian Geier, Dr. Bozena Polock, Dr. Björn Wendik, Sungmin Song, and Rebecca Mössner from the University of Freiburg as well as Dr. Verdon Taylor and Dr. Daniel Messerschmidt from the Freiburg Max Planck Institute. Wolfgang Driever and Jens Timmer are Internal Senior Fellows of the Freiburg Institute for Advanced Studies (FRIAS).


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Onichtchouk et al. Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development. Molecular Systems Biology, 2010; 6 DOI: 10.1038/msb.2010.9

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "Stem cell networks in zebrafish." ScienceDaily. ScienceDaily, 19 March 2010. <www.sciencedaily.com/releases/2010/03/100319210440.htm>.
Albert-Ludwigs-Universität Freiburg. (2010, March 19). Stem cell networks in zebrafish. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/03/100319210440.htm
Albert-Ludwigs-Universität Freiburg. "Stem cell networks in zebrafish." ScienceDaily. www.sciencedaily.com/releases/2010/03/100319210440.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins