Featured Research

from universities, journals, and other organizations

Bloome syndrome protein is critical for meiotic recombination

Date:
March 22, 2010
Source:
Rockefeller University Press
Summary:
Researchers have provided the first analysis of the function of Bloome syndrome protein (BLM) in mammalian meiosis. Bloome syndrome is a rare genetic disorder characterized by stunted growth, cancer predisposition, and sterility that is caused by a mutation in the Blm gene and a deficiency of BLM.

Researchers from Cornell University (NY) provide the first analysis of the function of Bloome syndrome protein (BLM) in mammalian meiosis. Bloome syndrome (BS) is a rare genetic disorder characterized by stunted growth, cancer predisposition, and sterility that is caused by a mutation in the Blm gene and a deficiency of BLM.

The study appears in the March 22 issue of the Journal of Cell Biology.

Although BLM has been shown to play an important role in DNA recombination in somatic cells, there has been no information on the impact of BLM in mammalian meiosis.

Now, a team led by Paula Cohen provides new data that indicate mouse BLM is involved in the proper pairing, synapsis, and segregation of homologous chromosomes during meiosis, but does not affect entry into the prophase I stage.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. K. Holloway, M. A. Morelli, P. L. Borst, P. E. Cohen. Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination. The Journal of Cell Biology, 2010; 188 (6): 779 DOI: 10.1083/jcb.200909048

Cite This Page:

Rockefeller University Press. "Bloome syndrome protein is critical for meiotic recombination." ScienceDaily. ScienceDaily, 22 March 2010. <www.sciencedaily.com/releases/2010/03/100322092047.htm>.
Rockefeller University Press. (2010, March 22). Bloome syndrome protein is critical for meiotic recombination. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/03/100322092047.htm
Rockefeller University Press. "Bloome syndrome protein is critical for meiotic recombination." ScienceDaily. www.sciencedaily.com/releases/2010/03/100322092047.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins