Featured Research

from universities, journals, and other organizations

Bloome syndrome protein is critical for meiotic recombination

Date:
March 22, 2010
Source:
Rockefeller University Press
Summary:
Researchers have provided the first analysis of the function of Bloome syndrome protein (BLM) in mammalian meiosis. Bloome syndrome is a rare genetic disorder characterized by stunted growth, cancer predisposition, and sterility that is caused by a mutation in the Blm gene and a deficiency of BLM.

Researchers from Cornell University (NY) provide the first analysis of the function of Bloome syndrome protein (BLM) in mammalian meiosis. Bloome syndrome (BS) is a rare genetic disorder characterized by stunted growth, cancer predisposition, and sterility that is caused by a mutation in the Blm gene and a deficiency of BLM.

Related Articles


The study appears in the March 22 issue of the Journal of Cell Biology.

Although BLM has been shown to play an important role in DNA recombination in somatic cells, there has been no information on the impact of BLM in mammalian meiosis.

Now, a team led by Paula Cohen provides new data that indicate mouse BLM is involved in the proper pairing, synapsis, and segregation of homologous chromosomes during meiosis, but does not affect entry into the prophase I stage.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. K. Holloway, M. A. Morelli, P. L. Borst, P. E. Cohen. Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination. The Journal of Cell Biology, 2010; 188 (6): 779 DOI: 10.1083/jcb.200909048

Cite This Page:

Rockefeller University Press. "Bloome syndrome protein is critical for meiotic recombination." ScienceDaily. ScienceDaily, 22 March 2010. <www.sciencedaily.com/releases/2010/03/100322092047.htm>.
Rockefeller University Press. (2010, March 22). Bloome syndrome protein is critical for meiotic recombination. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2010/03/100322092047.htm
Rockefeller University Press. "Bloome syndrome protein is critical for meiotic recombination." ScienceDaily. www.sciencedaily.com/releases/2010/03/100322092047.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins