Featured Research

from universities, journals, and other organizations

Memory may decline rapidly even in stage before Alzheimer's disease

Date:
March 23, 2010
Source:
American Academy of Neurology
Summary:
Memory and thinking skills may decline rapidly for people who have mild cognitive impairment, which is the stage before Alzheimer's disease when people have mild memory problems but no dementia symptoms, and even more rapidly when dementia begins, which is when Alzheimer's disease is usually diagnosed.

Memory and thinking skills may decline rapidly for people who have mild cognitive impairment, which is the stage before Alzheimer's disease when people have mild memory problems but no dementia symptoms, and even more rapidly when dementia begins, which is when Alzheimer's disease is usually diagnosed.

Related Articles


The research is published in the March 23, 2010, print issue of Neurology, the medical journal of the American Academy of Neurology.

"These results show that we need to pay attention to this time before Alzheimer's disease is diagnosed, when people are just starting to have problems forgetting things," said study author Robert S. Wilson, PhD, of Rush University Medical Center in Chicago.

The study involved 1,158 people living in Chicago with an average age of 79. A total of 149 of the participants had Alzheimer's disease, 395 had mild cognitive impairment, and 614 had no thinking or memory problems.

Memory and thinking skills tests were given to the participants at the beginning of the study and again every three years. People took part in the study for an average of 5.5 years, and up to 11 years.

The thinking skills of those with mild cognitive impairment declined twice as fast each year as those who had no cognitive problems, while the skills of those with Alzheimer's disease declined four times as fast as those with no cognitive problems.

At the beginning of the study, scores on a global cognition test ranged from an average of 0.5 for people with no thinking problems to 0.2 for people with mild cognitive impairment to -0.5 for people with Alzheimer's disease. Scores declined by 0.04 per year for those with no thinking problems, by 0.09 for those with mild cognitive impairment, and by 0.17 for those with Alzheimer's.

"The changes in rate of decline occur as the brain atrophies due to the disease, first mainly in the hippocampus during the initial symptomatic stage, referred to as mild cognitive impairment, then in the temporal, parietal and frontal cortex during the dementing illness phase of Alzheimer's disease," said David S. Knopman, MD, of the Mayo Clinic in Rochester, Minn., and Fellow of the American Academy of Neurology, who wrote an editorial accompanying the article.

The study was supported by the National Institute on Aging and the National Institute of Environmental Health Sciences.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Journal References:

  1. R. S. Wilson, N. T. Aggarwal, L. L. Barnes, C. F. Mendes de Leon, L. E. Hebert, and D. A. Evans. Cognitive decline in incident Alzheimer disease in a community population. Neurology, 2010; 74 (12): 951 DOI: 10.1212/WNL.0b013e3181d64786
  2. David S. Knopman. Mild cognitive impairment and on to dementia: Down the slippery slope but faster. Neurology, 2010; 74 (12): 942 DOI: 10.1212/WNL.0b013e3181d5dc61

Cite This Page:

American Academy of Neurology. "Memory may decline rapidly even in stage before Alzheimer's disease." ScienceDaily. ScienceDaily, 23 March 2010. <www.sciencedaily.com/releases/2010/03/100322171008.htm>.
American Academy of Neurology. (2010, March 23). Memory may decline rapidly even in stage before Alzheimer's disease. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2010/03/100322171008.htm
American Academy of Neurology. "Memory may decline rapidly even in stage before Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2010/03/100322171008.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins