Featured Research

from universities, journals, and other organizations

Most kidney transplant candidates will accept risk of infection

Date:
March 25, 2010
Source:
American Society of Nephrology
Summary:
Most kidney transplant candidates are willing to receive a kidney from a donor at increased risk of viral infection, according to a new study. The results suggest that kidney disease patients can make rational tradeoffs between the virtues and risks conferred by donated kidneys.

Most kidney transplant candidates are willing to receive a kidney from a donor at increased risk of viral infection, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that kidney disease patients can make rational tradeoffs between the virtues and risks conferred by donated kidneys.

Because thousands of patients die each year in the United States while waiting for a kidney transplant, greater efforts are needed to expand the pool of kidneys for transplantation. These efforts might include allowing patients to receive less-than-ideal organs, for example from deceased individuals at increased risk of viral infection. In these cases, patients must weigh the advantages of getting a transplant against the small risk of getting a serious infection such as HIV. The average dialysis patient has a 20% chance of dying annually, similar to the death rate from metastatic cancer. Therefore patients may decide that it's better to accept an organ from a donor at increased risk of viral infection than to remain on dialysis.

Peter Reese, MD, Scott Halpern MD, PhD (University of Pennsylvania) and their colleagues conducted a study to determine what proportion of kidney transplant candidates would accept a kidney from a donor at increased risk of viral infection. They also examined what factors influenced this decision.

The investigators studied 175 kidney transplant candidates who responded to hypothetical scenarios that tested their willingness to accept a kidney from a donor at higher risk of viral infection. Each scenario varied the donor age (as a substitute for kidney quality), the risk of contracting HIV and the waiting time until the next offer of a kidney transplant. Among 175 respondents, 42 (24.0%) rejected kidneys from donors at increased risk of viral infections under all conditions, 103 (58.9%) accepted them under some conditions, and 31 (17.7%) always accepted them. Patients were more likely to accept a kidney from donors at increased risk of viral infections when the donor was younger, HIV risk was lower, and when the waiting time was longer. Also, patients on dialysis and older patients more commonly accepted such kidneys.

Increasing the use of kidneys from donors at increased risk of viral infections could improve access to kidney transplantation only if transplant candidates are willing to accept these organs. "Our study shows that the majority of kidney transplant candidates would accept the tradeoff some of the time -- that is, they would accept a kidney transplant even if the risk of HIV infection was slightly elevated," said Dr. Reese.

According to the authors, transplant physicians should talk with their patients about the possibility of receiving organs from donors at increased risk of viral infections without fearing that such conversations will undermine the ability to place these organs.

Study co-authors include Tara Tehrani, MD, MaryAnn Lim, MD, David Asch, MD, Emily Blumberg, MD, Maureen Simon, RN and Roy Bloom, MD (University of Pennsylvania).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Determinants of the Decision to Accept a Kidney from a Donor at Increased Risk for Blood-Borne Viral Infection. Clinical Journal of the American Society Nephrology, March 25, 2010 DOI: 10.2215/CJN.08251109

Cite This Page:

American Society of Nephrology. "Most kidney transplant candidates will accept risk of infection." ScienceDaily. ScienceDaily, 25 March 2010. <www.sciencedaily.com/releases/2010/03/100325171215.htm>.
American Society of Nephrology. (2010, March 25). Most kidney transplant candidates will accept risk of infection. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2010/03/100325171215.htm
American Society of Nephrology. "Most kidney transplant candidates will accept risk of infection." ScienceDaily. www.sciencedaily.com/releases/2010/03/100325171215.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins