Featured Research

from universities, journals, and other organizations

Preclinical model of primary prostate cancer

Date:
March 25, 2010
Source:
American Journal of Pathology
Summary:
Researchers have developed a preclinical model of human prostate cancer that mimics the genetic and growth behavior of primary tumors.

A group led by Dr. Massimo Loda at the Dana Farber Cancer Institute, Boston, MA has developed a preclinical model of human prostate cancer that mimics the genetic and growth behavior of primary tumors.

Their report can be found in the April 2010 issue of the American Journal of Pathology.

Prostate cancer tends to develop in men over the age of 50 and is one of the most prevalent types of cancer in men. As prostate cancer is often slow-growing and symptom-free, treatment decisions are frequently based on a risk/benefit analysis determined by the underlying health and quality of life concerns of the patient.

Despite earlier detection and treatment of prostate cancer, novel biomarkers are needed to discriminate between aggressive and slow-developing tumors. Priolo et al therefore generated a preclinical model of human prostate cancer that mimics the genetic and growth behavior of primary tumors. In their model, the prostate cancer cells maintained both the histological and genetic characteristics of the parent tumor. In these mice, measurement of prostate-specific antigen levels correlated with tumor engraftment, but not engraftment of normal prostate tissue. Thus, this model should provide a platform for biomarker and drug discovery in prostate cancer.

Dr. Loda and colleagues conclude that "the mouse xenograft model that we have established through direct implantation of human primary prostate tumors represents a useful preclinical model for future applications in biological studies aimed at the identification of the most aggressive and possibly recurrent human localized prostate tumors as well as in biomarker discovery."

Priolo C, Agostini M, Vena N, Ligon AH, Fiorentino M, Shin E, Farsetti A, Pontecorvi A, Sicinska E, Loda M: Establishment and Genomic Characterization of Mouse Xenografts of Human Primary Prostate Tumors. Am J Pathol 2010, 176: 1901-1913


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Cite This Page:

American Journal of Pathology. "Preclinical model of primary prostate cancer." ScienceDaily. ScienceDaily, 25 March 2010. <www.sciencedaily.com/releases/2010/03/100325225442.htm>.
American Journal of Pathology. (2010, March 25). Preclinical model of primary prostate cancer. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2010/03/100325225442.htm
American Journal of Pathology. "Preclinical model of primary prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2010/03/100325225442.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins