Featured Research

from universities, journals, and other organizations

Blocking EphB4 impedes angiogenesis and tumor growth

Date:
March 25, 2010
Source:
American Journal of Pathology
Summary:
Researchers have found that antibodies to EphB4 inhibit new blood vessel and tumor growth.

Researchers led by Dr. Parkash Gill of the University of Southern California, Los Angeles, CA have found that antibodies to EphB4 inhibit new blood vessel and tumor growth.

Related Articles


They report their data in the April 2010 issue of the American Journal of Pathology.

Angiogenesis is the growth of new blood vessels from pre-existing vessels. It is critical in the progression and development of malignant tumors. The receptor tyrosine kinase EphB4, which is expressed in many epithelial cancers, plays a key role in angiogenesis.

Krasnoperov et al have developed two monoclonal antibodies against EphB4 that inhibit angiogenesis and tumor growth by two distinct mechanisms. MAb131 inhibits endothelial tube formation in vitro (a sign of angiogenesis) and tumor growth in vivo by inducing degradation of human EphB4. In contrast, although mAb147 does not degrade EphB4, it inhibits angiogenesis and tumor growth of both EphB4+ and EphB4- tumors, likely by modulating the vascular response. As humanized versions of both of these antibodies maintain these tumor-inhibitory functions, antibodies against EphB4 are strong candidates for clinical applications.

Dr. Gill's group "describe[s] novel EphB4-specific monoclonal antibodies that inhibit formation and maturation of newly forming vessels and inhibit tumor growth in vivo. … [They suggest that] antibodies targeting the EphB4 pathway, therefore, have the potential to inhibit tumor growth via multiple mechanisms."

Krasnoperov V, Kumar SR, Ley E, Li X, Scehnet J, Liu R, Zozulya S, Gil PS: Novel EphB4 Monoclonal antibodies modulate angiogenesis and inhibit tumor growth. Am J Pathol 2010, 176 2029-2038.


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Cite This Page:

American Journal of Pathology. "Blocking EphB4 impedes angiogenesis and tumor growth." ScienceDaily. ScienceDaily, 25 March 2010. <www.sciencedaily.com/releases/2010/03/100325225544.htm>.
American Journal of Pathology. (2010, March 25). Blocking EphB4 impedes angiogenesis and tumor growth. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2010/03/100325225544.htm
American Journal of Pathology. "Blocking EphB4 impedes angiogenesis and tumor growth." ScienceDaily. www.sciencedaily.com/releases/2010/03/100325225544.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins