Featured Research

from universities, journals, and other organizations

Blocking EphB4 impedes angiogenesis and tumor growth

Date:
March 25, 2010
Source:
American Journal of Pathology
Summary:
Researchers have found that antibodies to EphB4 inhibit new blood vessel and tumor growth.

Researchers led by Dr. Parkash Gill of the University of Southern California, Los Angeles, CA have found that antibodies to EphB4 inhibit new blood vessel and tumor growth.

They report their data in the April 2010 issue of the American Journal of Pathology.

Angiogenesis is the growth of new blood vessels from pre-existing vessels. It is critical in the progression and development of malignant tumors. The receptor tyrosine kinase EphB4, which is expressed in many epithelial cancers, plays a key role in angiogenesis.

Krasnoperov et al have developed two monoclonal antibodies against EphB4 that inhibit angiogenesis and tumor growth by two distinct mechanisms. MAb131 inhibits endothelial tube formation in vitro (a sign of angiogenesis) and tumor growth in vivo by inducing degradation of human EphB4. In contrast, although mAb147 does not degrade EphB4, it inhibits angiogenesis and tumor growth of both EphB4+ and EphB4- tumors, likely by modulating the vascular response. As humanized versions of both of these antibodies maintain these tumor-inhibitory functions, antibodies against EphB4 are strong candidates for clinical applications.

Dr. Gill's group "describe[s] novel EphB4-specific monoclonal antibodies that inhibit formation and maturation of newly forming vessels and inhibit tumor growth in vivo. … [They suggest that] antibodies targeting the EphB4 pathway, therefore, have the potential to inhibit tumor growth via multiple mechanisms."

Krasnoperov V, Kumar SR, Ley E, Li X, Scehnet J, Liu R, Zozulya S, Gil PS: Novel EphB4 Monoclonal antibodies modulate angiogenesis and inhibit tumor growth. Am J Pathol 2010, 176 2029-2038.


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Cite This Page:

American Journal of Pathology. "Blocking EphB4 impedes angiogenesis and tumor growth." ScienceDaily. ScienceDaily, 25 March 2010. <www.sciencedaily.com/releases/2010/03/100325225544.htm>.
American Journal of Pathology. (2010, March 25). Blocking EphB4 impedes angiogenesis and tumor growth. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/03/100325225544.htm
American Journal of Pathology. "Blocking EphB4 impedes angiogenesis and tumor growth." ScienceDaily. www.sciencedaily.com/releases/2010/03/100325225544.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins