Featured Research

from universities, journals, and other organizations

Promising hormone may help reduce malnutrition in gastric cancer patients

Date:
March 31, 2010
Source:
American Gastroenterological Association
Summary:
In gastric cancer patients who have had part or all of their stomach removed, the hormone ghrelin may lessen post-operative weight loss and improve appetite.

In gastric cancer patients who have had part or all of their stomach removed, the hormone ghrelin may lessen post-operative weight loss and improve appetite, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

"It is our obligation to invent novel procedures to minimize the side effects of gastrectomy. Our study provides convincing data for the beneficial effects of ghrelin -- the only gastrointestinal hormone known to stimulate appetite -- on body weight and dietary activity after gastrectomy," said Shuji Takiguchi, MD, of Osaka University's Graduate School of Medicine and lead author of the study. "Although there are some issues to be resolved before clinical use, surgeons dealing with gastric cancers and other gastroesophageal diseases should be encouraged by the availability of ghrelin."

In this randomized phase II study, doctors assigned 20 gastrectomy patients to receive either ghrelin (10 patients) or placebo (10 patients) via IV twice a day for 10 days after starting oral food intake following surgery. Changes in body weight, appetite, food intake, body composition, metabolic rate and various blood tests were evaluated.

When comparing both groups, food intake (average 13.8 versus 10.4 kcal/kg/day) and appetite (5.7 versus 3.9 cm) were significantly higher in the ghrelin group than in the placebo group, respectively. Body weight loss was significantly lower in the ghrelin group than in the placebo group (-1.4 percent versus -3.7 percent). Fat mass, lean body mass and metabolic rate decreased significantly in the placebo group. Although the reductions in lean body mass and metabolic rate were not significant in the ghrelin group, the fat mass reduction was significant.

Body weight loss is a common and serious outcome in patients with gastric cancer who have undergone total gastrectomy, or excision of the stomach. It may also lead to a decline in post-operative quality of life and is the most reliable indicator of malnutrition, which impairs immune function, infection susceptibility and survival. Although various factors have been considered, reduced food intake is the most conceivable explanation for body weight loss after gastrectomy.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Cite This Page:

American Gastroenterological Association. "Promising hormone may help reduce malnutrition in gastric cancer patients." ScienceDaily. ScienceDaily, 31 March 2010. <www.sciencedaily.com/releases/2010/03/100331141017.htm>.
American Gastroenterological Association. (2010, March 31). Promising hormone may help reduce malnutrition in gastric cancer patients. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2010/03/100331141017.htm
American Gastroenterological Association. "Promising hormone may help reduce malnutrition in gastric cancer patients." ScienceDaily. www.sciencedaily.com/releases/2010/03/100331141017.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins