Featured Research

from universities, journals, and other organizations

Brain tumors: Tissue stem cell turning into tumor stem cell

Date:
April 6, 2010
Source:
Helmholtz Association of German Research Centres
Summary:
Scientists have shown for the first time that malignant brain tumors arise directly from brain stem cells. Overproduction of the protein Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. Tlx also plays an important role in glioblastoma, the most malignant of human brain cancers. Therefore, the discovery of Tlx might provide the first target for a specific therapy against glioblastoma.

Mice overexpressing Tlx develop glioma initiating lesions.
Credit: Haikun Liu, German Cancer Research Center

The "cradle" of new neurons in the adult brain is well known. It is what is called the subventricular zone, a tissue structure lining the lateral ventricles. This is where neural or brain stem cells reside, which are responsible for generating new neurons if needed. For many years now, the subventricular zone has been suspected to be the origin of specific malignant brain tumors called gliomas, the most deadly type of which is glioblastoma.

Related Articles


Scientists from the divisions of Professor Dr. Günther Schütz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. In the adult animal, Tlx is expressed exclusively in brain stem cells. When the scientists switched off Tlx, there were no more detectable stem cells in the brain and the formation of new neurons ceased. Functioning of the stem cells thus appears to depend on the presence of this protein.

In their recent study, the teams headed by Günther Schütz and Peter Lichter, jointly with Professor Dr. Guido Reifenberger of Düsseldorf University, have now tested the opposite case: What happens if the production of Tlx is increased? Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. In another experiment in which the researchers additionally switched off the p53 protein as an important cancer brake, invasively growing glioblastomas arose from the cancer precursors.

Moreover, the scientists discovered that stem cells with increased Tlx production stimulate the formation of new vessels. This enables the cells to migrate into distant brain regions and, thus, to generate the typical coral-like growth of glioblastoma.

"We recognize brain stem cells specifically by their Tlx production. If we boost it, the tissue stem cell turns into a cancer stem cell from which malignant glioblastomas arise. Therefore, we are now able, for the first time, to hold brain stem cells directly responsible for the formation of brain tumor stem cells," Günther Schütz explains.

The researchers expect to be able to develop new therapies to treat glioblastoma on the basis of these results from fundamental cell biology research. Tlx seems to play its fatal role not only in mouse brains. Studying tumor tissue from glioblastoma patients, Lichter and Reifenberger discovered that the Tlx gene is often present in multiple copies and, thus, more Tlx protein is produced. "Apparently, human brain tumor stem cells also depend on Tlx. Therefore, we can now try to develop therapies that are directed very specifically against Tlx producing cells," said Schütz describing the next steps. The mice whose brain stem cells overproduce Tlx are an ideal model system for such investigations.


Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hai-Kun Liu, Ying Wang, Thorsten Belz, Dagmar Bock, Andrea Takacs, Bernhard Radlwimmer, Sebastian Barbus, Guido Reifenberger, Peter Lichter and Günther Schütz. The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes & Development, 2010; 24 (7): 683 DOI: 10.1101/gad.560310

Cite This Page:

Helmholtz Association of German Research Centres. "Brain tumors: Tissue stem cell turning into tumor stem cell." ScienceDaily. ScienceDaily, 6 April 2010. <www.sciencedaily.com/releases/2010/04/100401100957.htm>.
Helmholtz Association of German Research Centres. (2010, April 6). Brain tumors: Tissue stem cell turning into tumor stem cell. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/04/100401100957.htm
Helmholtz Association of German Research Centres. "Brain tumors: Tissue stem cell turning into tumor stem cell." ScienceDaily. www.sciencedaily.com/releases/2010/04/100401100957.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins