Featured Research

from universities, journals, and other organizations

Discovery of new group of molecules could help fight spread of cancer and other diseases

Date:
April 5, 2010
Source:
University of East Anglia
Summary:
A team of scientists has discovered a new group of molecules which could help fight the spread of cancer and other diseases. The new molecules are synthetic derivatives of a natural product known as UDP-Galactose, and block the activity of a group of enzymes called glycosyltransferases.

A team of scientists led by the University of East Anglia (UEA) has discovered a brand new group of molecules which could help fight the spread of cancer and other diseases.

Related Articles


The new molecules are synthetic derivatives of a natural product known as UDP-Galactose, and block the activity of a group of enzymes called glycosyltransferases. Glycosyltransferases are used by biological cells to turn simple sugars into elongated sugar chains and branched structures.

Published online by the journal Nature Chemical Biology, the findings could lead to a significant therapeutic advance in the treatment of cancer, inflammation and infection.

Many biological cells -- including cancer cells and bacterial cells -- are literally covered by a coating of sugar. This sugar coating influences the way cells communicate with their environment and with each other.

For example, when a cancer spreads through the body or a bacterium infiltrates its human host many of the contacts the rogue cells make with other cells are through these sugars on their cell surface.

To form the complex sugar structures that decorate their surface, cells rely on gylcosyltransferases to join individual sugar building blocks together. The UEA researchers have found that synthetic UDP-Galactose derivatives block these enzymes effectively. These molecules can therefore potentially be used to interfere with harmful biological processes such as cancer metastasis and bacterial infection.

The work was carried out by researchers at UEA's School of Pharmacy, working alongside colleagues at the Carlsberg Research Centre in Denmark.

"This exciting discovery of a potent enzyme inhibitor with a completely new mechanism of action has considerable therapeutic potential in cancer, inflammation and infection," said lead author Dr Gerd Wagner of UEA.

"Our results also provide a general strategy for how to design and improve such inhibitors in the future. The 'snapshots' we have taken of one of these enzymes, together with the new inhibitor itself, can provide very valuable guidance for the development of new anti-cancer and anti-infective drug candidates."


Story Source:

The above story is based on materials provided by University of East Anglia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas Pesnot, Rene Jψrgensen, Monica M Palcic, Gerd K Wagner. Structural and mechanistic basis for a new mode of glycosyltransferase inhibition. Nature Chemical Biology, 2010; DOI: 10.1038/nchembio.343

Cite This Page:

University of East Anglia. "Discovery of new group of molecules could help fight spread of cancer and other diseases." ScienceDaily. ScienceDaily, 5 April 2010. <www.sciencedaily.com/releases/2010/04/100404203122.htm>.
University of East Anglia. (2010, April 5). Discovery of new group of molecules could help fight spread of cancer and other diseases. ScienceDaily. Retrieved March 26, 2015 from www.sciencedaily.com/releases/2010/04/100404203122.htm
University of East Anglia. "Discovery of new group of molecules could help fight spread of cancer and other diseases." ScienceDaily. www.sciencedaily.com/releases/2010/04/100404203122.htm (accessed March 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) — While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com
Obama: Affordable Care Act 'saving Lives'

Obama: Affordable Care Act 'saving Lives'

AP (Mar. 25, 2015) — Speaking at a White House event marking the fifth anniversary of the Affordable Care Act, President Barack Obama says the law is "saving lives that touch all of us." (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins