Featured Research

from universities, journals, and other organizations

Immune sensors suppress colitis-associated cancer

Date:
April 15, 2010
Source:
Rockefeller University Press
Summary:
Particular components of inflammasomes -- protein complexes needed for generating immune responses to pathogens and cellular damage -- lessen the severity of colitis and colitis-associated colon cancer in mice, according to a new study.

Particular components of inflammasomes -- protein complexes needed for generating immune responses to pathogens and cellular damage -- lessen the severity of colitis and colitis-associated colon cancer in mice, according to a study published online this week in the Journal of Experimental Medicine.

Compared to healthy humans, patients with ulcerative colitis, a form of inflammatory bowel disease, have a higher risk of developing colorectal cancer. As the inflammasome is typically associated with activation of the immune system, Jenny Ting and co-workers suspected that mice lacking inflammasome components would be more resistant to colitis and associated colorectal cancer.

Unexpectedly, mice lacking some but not all inflammasome components developed more severe colitis and larger tumor burdens in the colon.

Additional work is needed to determine how specific inflammasome components protect against colitis in mice, and whether inflammasomes play similar roles in humans.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Irving C. Allen, Erin Mcelvania Tekippe, Rita-Marie T. Woodford, Joshua M. Uronis, Eda K. Holl, Arlin B. Rogers, Hans H. Herfarth, Christian Jobin, and Jenny P.-Y. Ting. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med, April 12, 2010 DOI: 10.1084/jem.20100050

Cite This Page:

Rockefeller University Press. "Immune sensors suppress colitis-associated cancer." ScienceDaily. ScienceDaily, 15 April 2010. <www.sciencedaily.com/releases/2010/04/100412095533.htm>.
Rockefeller University Press. (2010, April 15). Immune sensors suppress colitis-associated cancer. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2010/04/100412095533.htm
Rockefeller University Press. "Immune sensors suppress colitis-associated cancer." ScienceDaily. www.sciencedaily.com/releases/2010/04/100412095533.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins