Featured Research

from universities, journals, and other organizations

Immune sensors suppress colitis-associated cancer

Date:
April 15, 2010
Source:
Rockefeller University Press
Summary:
Particular components of inflammasomes -- protein complexes needed for generating immune responses to pathogens and cellular damage -- lessen the severity of colitis and colitis-associated colon cancer in mice, according to a new study.

Particular components of inflammasomes -- protein complexes needed for generating immune responses to pathogens and cellular damage -- lessen the severity of colitis and colitis-associated colon cancer in mice, according to a study published online this week in the Journal of Experimental Medicine.

Compared to healthy humans, patients with ulcerative colitis, a form of inflammatory bowel disease, have a higher risk of developing colorectal cancer. As the inflammasome is typically associated with activation of the immune system, Jenny Ting and co-workers suspected that mice lacking inflammasome components would be more resistant to colitis and associated colorectal cancer.

Unexpectedly, mice lacking some but not all inflammasome components developed more severe colitis and larger tumor burdens in the colon.

Additional work is needed to determine how specific inflammasome components protect against colitis in mice, and whether inflammasomes play similar roles in humans.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Irving C. Allen, Erin Mcelvania Tekippe, Rita-Marie T. Woodford, Joshua M. Uronis, Eda K. Holl, Arlin B. Rogers, Hans H. Herfarth, Christian Jobin, and Jenny P.-Y. Ting. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med, April 12, 2010 DOI: 10.1084/jem.20100050

Cite This Page:

Rockefeller University Press. "Immune sensors suppress colitis-associated cancer." ScienceDaily. ScienceDaily, 15 April 2010. <www.sciencedaily.com/releases/2010/04/100412095533.htm>.
Rockefeller University Press. (2010, April 15). Immune sensors suppress colitis-associated cancer. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2010/04/100412095533.htm
Rockefeller University Press. "Immune sensors suppress colitis-associated cancer." ScienceDaily. www.sciencedaily.com/releases/2010/04/100412095533.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins