Featured Research

from universities, journals, and other organizations

Growth curve analyses of Finnish population shed light on the genetic regulation of growth in height

Date:
April 15, 2010
Source:
University of Helsinki
Summary:
Researchers in Finland have shown that a gene called LIN28B strongly influences height growth from birth to adulthood in a complex and sex-specific manner.

Researchers at the University of Helsinki and the Institute for Molecular Medicine Finland (FIMM) have shown that a gene called LIN28B strongly influences height growth from birth to adulthood in a complex and sex-spesific manner.

Related Articles


Human growth in height is a multifaceted process including periods of accelerated and decelerated growth velocities. The postnatal growth trajectory can be conceptualized as consisting of three partially overlapping phases: infant growth characterized by rapidly declining growth velocities, slowly decelerating childhood growth, and the pubertal height growth spurt.

Height is strongly regulated by genes, and so far more than 40 genes have been implicated influencing adult height. Yet, little is known about how individual genes regulate growth in height.

Utilizing the unique resource of longitudinal childhood height growth data available in Finnish population cohorts, researchers at the University of Helsinki and the Institute for Molecular Medicine Finland (FIMM) have pinpointed broad height growth regulating effects to a gene called LIN28B. The same gene is known to be a key regulator of developmental timing in the nematode C. elegans and has previously been associated both with timing of menarche and adult height in humans.

Applying genome-wide association mapping technology, the researchers have now shown that the gene strongly influences the timing of the pubertal height growth spurt both in males and females but they also found that it regulates height growth from birth to adulthood in a complex and sex-specific manner.

"Interestingly; two separate variants of the gene were found to influence growth, one with a more prominent height increasing effect in males and another one increasing height only in females," tells Academy Research Fellow, Dr. Elisabeth Widén.


Story Source:

The above story is based on materials provided by University of Helsinki. Note: Materials may be edited for content and length.


Journal Reference:

  1. Elisabeth Widén , Samuli Ripatti , Diana L. Cousminer , Ida Surakka , Tuuli Lappalainen , Marjo-Riitta Järvelin , Johan G. Eriksson , Olli Raitakari , Veikko Salomaa , Ulla Sovio , Anna-Liisa Hartikainen , Anneli Pouta , Mark I. McCarthy , Clive Osmond , Eero Kajantie , Terho Lehtimäki , Jorma Viikari , Mika Kähönen , Chris Tyler-Smith , Nelson Freimer , Joel N. Hirschhorn , Leena Peltonen and Aarno Palotie. Distinct Variants at LIN28B Influence Growth in Height from Birth to Adulthood. American Journal of Human Genetics, 2010; DOI: 10.1016/j.ajhg.2010.03.010

Cite This Page:

University of Helsinki. "Growth curve analyses of Finnish population shed light on the genetic regulation of growth in height." ScienceDaily. ScienceDaily, 15 April 2010. <www.sciencedaily.com/releases/2010/04/100415125945.htm>.
University of Helsinki. (2010, April 15). Growth curve analyses of Finnish population shed light on the genetic regulation of growth in height. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2010/04/100415125945.htm
University of Helsinki. "Growth curve analyses of Finnish population shed light on the genetic regulation of growth in height." ScienceDaily. www.sciencedaily.com/releases/2010/04/100415125945.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) — Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) — Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) — Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) — At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins