Featured Research

from universities, journals, and other organizations

Scientists isolate portion of virus that causes pink eye

Date:
April 16, 2010
Source:
Massachusetts Eye and Ear Infirmary
Summary:
Viral keratoconjunctivitis, also known as pink eye, is a common, uncomfortable and highly contagious condition. But now, relief may be in sight with a new understanding of how the eye reacts to this virus. Researchers used a novel model to determine what part of the virus is responsible for inflammation in pink eye.

Viral keratoconjunctivitis, also known as pink eye, is a common, uncomfortable and highly contagious condition. There is no known effective treatment for this adenovirus infection that can force some individuals into isolation for up to two weeks. The virus is resilient and can remain infectious for up to 30 days on a plastic surface. Infection with the adenovirus causes inflammation, which results in red, irritated eyes, blurry vision and discharge.

But now, relief may be in sight with a new understanding of how the eye reacts to this virus. Researchers in the Howe Laboratory, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary and Harvard Medical School, and in the University of Oklahoma Health Sciences Center, used a novel model to determine what part of the virus is responsible for inflammation in pink eye. Their findings are outlined in the April 15 issue of PLoS Pathogens.

"We were interested in understanding what part of the human adenovirus causes inflammation. We found that it is the protein coating around the virus that is most inflammatory in the eye. This is important because without inflammation, there would be no discharge from the eye, and therefore no transmission. Now that we know what causes the inflammation, we hope to find a way to block it," said James Chodosh, M.D., M.P.H,, Mass. Eye and Ear cornea surgeon and senior author of the paper.

Using a unique mouse model of adenovirus keratitis, Dr. Chodosh and his team studied the role of viral components in the cornea to determine which viral part(s) induce an innate immune response. The authors found that neither viral DNA nor viral gene expression was necessary for inflammation. In contrast, viral capsid, the protein coat of the virus, induced inflammation similar to intact virus. Mice lacking the toll-like receptor 9 molecule, which acts as a pathogen DNA-sensing molecule within the cell, developed clinical inflammation upon adenovirus infection similar to wild type mice. Virus associated inflammation in the mouse cornea could be blocked by a treatment with a peptide containing components of the adenoviral capsid. Adenovirus infection of the cornea induces inflammation principally through contact between the viral capsid and the host cell.

"Our study provides new insights into how the innate immune system in the eye responds to a clinically important viral pathogen," Dr. Chodosh said. "With the new understanding, we are a step closer to developing a treatment for this common -- and highly contagious -- eye condition."

In addition to Dr. Chodosh, who an Instructor in Ophthalmology at Harvard Medical School in addition to his Mass. Eye and Ear affiliation, the authors of the paper include: Xiaohong Zhou and Jaya Rajaiya, both who are now Research Instructors in the Department of Ophthalmology at Harvard Medical School, and Ashish Chintakuntlawar, who was a postdoctoral fellow. Funding for the research was provided by a grant from the National Institutes of Health, National Eye Institute.


Story Source:

The above story is based on materials provided by Massachusetts Eye and Ear Infirmary. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ashish V. Chintakuntlawar, Xiaohong Zhou, Jaya Rajaiya, James Chodosh. Viral Capsid Is a Pathogen-Associated Molecular Pattern in Adenovirus Keratitis. PLoS Pathogens, 2010; 6 (4): e1000841 DOI: 10.1371/journal.ppat.1000841

Cite This Page:

Massachusetts Eye and Ear Infirmary. "Scientists isolate portion of virus that causes pink eye." ScienceDaily. ScienceDaily, 16 April 2010. <www.sciencedaily.com/releases/2010/04/100415171400.htm>.
Massachusetts Eye and Ear Infirmary. (2010, April 16). Scientists isolate portion of virus that causes pink eye. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/04/100415171400.htm
Massachusetts Eye and Ear Infirmary. "Scientists isolate portion of virus that causes pink eye." ScienceDaily. www.sciencedaily.com/releases/2010/04/100415171400.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins