Featured Research

from universities, journals, and other organizations

Early predictors of severe acute pancreatitis

Date:
April 19, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Lithuania and Germany investigated the secretion patterns of pro- and anti-inflammatory cytokines, and estimated the activation of various cellular subsets of leukocytes in peripheral blood of patients with severe and mild acute pancreatitis (AP). They suggest that molecules such as serum interleukin-6 and macrophage migration inhibitory factor could be used as markers for patient stratification and/or predicting the outcomes of AP in the early stages of the disease.

Mortality of patients with severe acute pancreatitis (SAP) approaches 30%-40%. An imbalance between the early systemic inflammatory response syndrome (SIRS), and the later compensatory counter-inflammatory response, and development of multiple organ failure (MOF) are considered to be the primary causes of morbidity and mortality in SAP.

Excessive leukocyte activation (including neutrophils and monocyte-macrophage lineage) with cytokinemia play a critical role in the pathogenesis of pancreatitis and even more so, of the subsequent inflammatory response. It has been hypothesized that fatal pancreatitis is a consequence of abnormal phagocytic leukocyte hyperstimulation due to deregulation in T- and B-lymphocyte activation. However, the role of lymphocyte activation and its relation to the severity of disease in humans is still poorly understood.

Another important drawback is that the majority of information about the alterations of the immune system during the AP comes from in vitro and in vivo studies, and therefore is not always directly applicable and relevant to the clinical situation in human AP.

A research article to be published on April 21, 2010 in the World Journal of Gastroenterology addresses this question. The research team led by Dambrauskas from Department of Surgery, Kaunas University of Medicine, confirmed that human severe and necrotizing AP is characterized by the significant depletion of circulating lymphocytes.

The study demonstrates that serum interleukin (IL)-6 and macrophage migration inhibitory factor (MIF) concentrations are the best discriminators of severe and necrotiz¬ing AP as well as possible fatal outcome during the early course of the disease. These cytokines could also be used as early predictors of local (pancreatic necrosis) and systemic complications (SIRS, MOF) later in the course of the disease. Deregulation of the cellular immune system is a key event leading to the development of severe and necrotizing AP. Infiltration of peripheral organs by aberrantly activated inflammatory cells leads to the development of MOF.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dambrauskas Z, Giese N, Gulbinas A, Giese T, Berberat PO, Pundzius J, Barauskas G, Friess H. Different profiles of cytokine expression during mild and severe acute pancreatitis. World Journal of Gastroenterology, 2010; 16 (15): 1845 DOI: 10.3748/wjg.v16.i15.1845

Cite This Page:

World Journal of Gastroenterology. "Early predictors of severe acute pancreatitis." ScienceDaily. ScienceDaily, 19 April 2010. <www.sciencedaily.com/releases/2010/04/100419102417.htm>.
World Journal of Gastroenterology. (2010, April 19). Early predictors of severe acute pancreatitis. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2010/04/100419102417.htm
World Journal of Gastroenterology. "Early predictors of severe acute pancreatitis." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419102417.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins