Featured Research

from universities, journals, and other organizations

The promise of DNA vaccines

Date:
April 22, 2010
Source:
Mary Ann Liebert, Inc./Genetic Engineering News
Summary:
Laboratory research and clinical studies are beginning to demonstrate that DNA vaccines can be as effective as traditional vaccines. A number of factors are driving the growth of the field, especially new approaches to electroporation, vaccine formulation, and vector design.

Laboratory research and clinical studies are beginning to demonstrate that DNA vaccines can be as effective as traditional vaccines, reports Genetic Engineering & Biotechnology News (GEN). A number of factors are driving the growth of the field, especially new approaches to electroporation, vaccine formulation, and vector design, according to the April 15 issue of GEN.

"A lot of development is focused on the creation of DNA vaccines for humans," says John Sterling, Editor in Chief of GEN. "Many of the advances being made are due to the introduction of new technologies and improvements in older methodologies."

For example, scientists at the Karolinska Institute and Tripep are working on a therapeutic vaccine for hepatitis C virus. A major impediment to successful DNA vaccination has been the failure to achieve sufficient uptake of the DNA by host tissue. This roadblock caused the collapse of a number of clinical trials a decade ago. The problems have now been resolved through improvements in transfection techniques, specifically electroporation. Inovio Biomedical, in particular, has aggressively pursued development of a minimally invasive electroporation device.

In addition, Althea Technologies has developed a high cell density fermentation and purification process for plasmid DNA products that reportedly provides plasmid yields in the range of 100-2,000 mg/L depending on plasmid size and bacterial strain. The company offers services in plasmid design and production, and possesses core capabilities in biological process development.

Also discussed in the GEN article is DNA vaccine-related work being carried out at BIA Separations, Nature Technology, the Walter Reed Army Research Institute, and VGXI.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. John Morrow Jr., Ph.D. DNA Vaccines Hit Their Stride with Approvals Anticipated. Genetic Engineering & Biotechnology News, Apr 15 2010 (Vol. 30, No. 8) [link]

Cite This Page:

Mary Ann Liebert, Inc./Genetic Engineering News. "The promise of DNA vaccines." ScienceDaily. ScienceDaily, 22 April 2010. <www.sciencedaily.com/releases/2010/04/100419132450.htm>.
Mary Ann Liebert, Inc./Genetic Engineering News. (2010, April 22). The promise of DNA vaccines. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/04/100419132450.htm
Mary Ann Liebert, Inc./Genetic Engineering News. "The promise of DNA vaccines." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419132450.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins