Featured Research

from universities, journals, and other organizations

Does a man's estrogen level impact his risk of prostate cancer?

Date:
April 22, 2010
Source:
Georgetown University Medical Center
Summary:
A high level of one type of estrogen in a man's body might increase his risk of developing prostate cancer. That is one surprising conclusion from a new study which also offers another novel finding -- that high levels of the estrogen considered fuel for breast cancer might offer a protective benefit against prostate cancer.

A high level of one type of estrogen in a man's body might increase his risk of developing prostate cancer. That is one surprising conclusion from a new study which also offers another novel finding -- that high levels of the estrogen considered fuel for breast cancer might offer a protective benefit against prostate cancer.

Related Articles


Details of the research were recently presented at the AACR 101st Annual Meeting 2010.

The health of the prostate has long been considered dependent on the level of the male hormones collectively known as androgens however, it is now recognized that estrogens and their metabolites (estrogen broken down by chemical processes in the body) play a role in its normal growth as well as in prostate cancer.

"The aim of our study was to evaluate the use of estrogen metabolites, as a marker for prostate cancer risk," says Ourania Kosti, PhD, at Georgetown Lombardi Comprehensive Cancer Center.

For the study, the researchers measured estrogens and their metabolites in the urine collected from 77 men with prostate cancer, 77 healthy controls and 37 men that underwent biopsy and but were diagnosed cancer-free.

The relative amounts of the 15 estrogens and estrogen metabolites in the urine of prostate cancer cases were similar to that of non-cancer patients with the exception of the estrogen metabolite 4-OHE1.

"This particular estrogen metabolite appeared to be more abundant among men diagnosed with prostate cancer," explains Kosti.

Kosti says her team also observed that the estrogen metabolites considered as 'harmful' estrogens in breast cancer (16-KE2 and 17-epiE3) are secreted in higher amounts among those without prostate cancer and in lower amounts in those with prostate cancer.

"This suggests that these particular estrogens may have a protective role against prostate cancer development," explains Kosti. "It is possible that different tissues respond to estrogens different ways, therefore the potential role of 16-KE2 and 17-epiE3 in prostate cancer prevention and management should be further explored."


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Does a man's estrogen level impact his risk of prostate cancer?." ScienceDaily. ScienceDaily, 22 April 2010. <www.sciencedaily.com/releases/2010/04/100419150813.htm>.
Georgetown University Medical Center. (2010, April 22). Does a man's estrogen level impact his risk of prostate cancer?. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2010/04/100419150813.htm
Georgetown University Medical Center. "Does a man's estrogen level impact his risk of prostate cancer?." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419150813.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins