Featured Research

from universities, journals, and other organizations

Breathe easy with the protein LPCAT1

Date:
April 26, 2010
Source:
Journal of Clinical Investigation
Summary:
The leading cause of death in infants born prematurely is respiratory distress syndrome. It is caused by deficiency in a fat-protein complex known as lung surfactant, which is critical for optimal gas exchange in the lung. New research indicates that the protein LPCAT1 has a crucial role in surfactant generation in vivo in mice and that LPCAT1 activity must be maximal for the transition from the womb to air breathing.

The leading cause of death in infants born prematurely is respiratory distress syndrome. It is caused by deficiency in a fat-protein complex known as lung surfactant, which is critical for optimal gas exchange in the lung. LPCAT1 is a recently identified mouse lung protein predicted, based on in vitro assays, to be involved in the generation of surfactant.

Related Articles


Now, John Shannon and colleagues, at Cincinnati Children's Hospital Medical Center, have demonstrated that LPCAT1 has a crucial role in the generation of surfactant in vivo in mice and that the activity of this protein must be maximal for the transition from the womb to air breathing.

They therefore speculate that decreased LPCAT1 expression, as a result of mutations in the gene responsible for making this protein, might underlie the fatal respiratory distress syndrome observed in a subset of newborn infants.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. James P. Bridges, Machiko Ikegami, Lauren L. Brilli, Xueni Chen, Robert J. Mason and John M. Shannon. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI38061

Cite This Page:

Journal of Clinical Investigation. "Breathe easy with the protein LPCAT1." ScienceDaily. ScienceDaily, 26 April 2010. <www.sciencedaily.com/releases/2010/04/100419172850.htm>.
Journal of Clinical Investigation. (2010, April 26). Breathe easy with the protein LPCAT1. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/04/100419172850.htm
Journal of Clinical Investigation. "Breathe easy with the protein LPCAT1." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419172850.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) — Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) — Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) — The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins