Featured Research

from universities, journals, and other organizations

In breasts considered 'healthy,' too much of one protein identifies abnormal growth

Date:
April 24, 2010
Source:
Georgetown University Medical Center
Summary:
By examining tissue removed during breast reduction surgery in healthy women, researchers have found a molecule they say identified women who had atypical hyperplasia, a potentially precancerous condition in which cells are abnormally increased.

By examining tissue removed during breast reduction surgery in healthy women, researchers at Georgetown Lombardi Comprehensive Center have found a molecule they say identified women who had atypical hyperplasia, a potentially precancerous condition in which cells are abnormally increased.

Related Articles


Their findings, presented at the AACR 101st Annual Meeting 2010, suggest that this protein, transforming growth factor beta 1 (TGF-β1), could be part of a panel of genes and proteins that physicians might one day use to identify women who are at future risk of developing breast cancer. Such a test would allow women at risk to receive appropriate monitoring, counseling, and potential preventive treatment.

"Our study indicates that higher than normal levels of TGF-β1 in breast cells may be important in the very beginning of the cancer process," says the study's lead investigator, Jose Angel Montero Santamaria, a tumor biology PhD student who is conducting research in the laboratory of Peter Shields, MD, professor in the departments of oncology and medicine and deputy director of Lombardi.

TGF-β1 is essential for the normal housekeeping of a cell, which requires a balance of cell growth and cell death, Santamaria says. Normally, it exhibits a Dr. Jekyll-like role, controlling normal growth, but once a cell begins to morph toward cancer, TGF-β1 is over-produced and exhibits its Mr. Hyde side, promoting the malignant transformation process.

In this study, Santamaria examined breast tissue samples donated from 92 healthy women undergoing breast reduction surgery. Santamaria's team examined RNA and protein expression from 75 of these samples. By examining the cells carefully, they were able to identify nine women with proliferative lesions, and a molecular and histological test showed over production of TGF-β1 in all of these women's breast tissue samples.

"The changes in their tissue can not be seen on a mammogram any other screening process we use today, which is why we are trying to develop a panel of molecular tests that will accurately determine an individual woman's future risk of developing breast cancer," Santamaria says.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "In breasts considered 'healthy,' too much of one protein identifies abnormal growth." ScienceDaily. ScienceDaily, 24 April 2010. <www.sciencedaily.com/releases/2010/04/100420142033.htm>.
Georgetown University Medical Center. (2010, April 24). In breasts considered 'healthy,' too much of one protein identifies abnormal growth. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2010/04/100420142033.htm
Georgetown University Medical Center. "In breasts considered 'healthy,' too much of one protein identifies abnormal growth." ScienceDaily. www.sciencedaily.com/releases/2010/04/100420142033.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins