Featured Research

from universities, journals, and other organizations

Nitric oxide-donating naproxen can boost colorectal cancer prevention, study suggests

Date:
April 21, 2010
Source:
Fox Chase Cancer Center
Summary:
Past randomized clinical trials have shown that non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, can reduce the risk of colon cancer and precancerous polyps in humans. Now, researchers have found that an investigational form of naproxen, called nitric oxide-donating naproxen (NO-naproxen), can block one of the earliest molecular changes that lead to colorectal cancer development while also reducing gastrointestinal toxicity, a relatively common side effect associated with NSAIDs.

Past randomized clinical trials have shown that non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, can reduce the risk of colon cancer and precancerous polyps in humans. Now, researchers at Fox Chase Cancer Center have found that an investigational form of naproxen, called nitric oxide-donating naproxen (NO-naproxen), can block one of the earliest molecular changes that lead to colorectal cancer development while also reducing gastrointestinal toxicity, a relatively common side effect associated with NSAIDs.

"It appears that the investigational form of naproxen we studied may be more effective than standard naproxen in inhibiting colorectal tumor development," says Margie Clapper, Ph.D., Co-Leader of the Cancer Prevention and Control Program at Fox Chase Cancer Center. "An added benefit would be the reduced gastrointestinal toxicity of this novel type of naproxen." Clapper's group will present the new data at the 2010 annual meeting of the American Association for Cancer Research.

"This new form of naproxen is probably more protective because it blocks one of the first steps in the colorectal cancer-causing pathway," she says.

Previous work from Clapper and others has shown that increased activity of the WNT/-catenin pathway is one of the earliest events in colorectal cancer formation. To test whether NO-naproxen could reduce activation of the pathway, the team used colon cancer cells that become bioluminescent when the WNT/-catenin pathway is active. They found that cells treated with NO-naproxen had about 50% less bioluminescence than cells treated with naproxen.

"The major and novel finding from the study is that the NO-naproxen can alter a particular signaling pathway that is one of the earliest events in colon cancer formation," Clapper says. "Based on the in vitro data, we think that NO-naproxen is much better than naproxen in nipping this whole process in the bud."

To confirm the in vitro results, the team has treated mice that are genetically predisposed to develop colorectal adenomas with NO-naproxen and naproxen and are awaiting the results of this study.

NSAIDs have been shown to reduce the risk of colon cancer and precancerous polyps in people. However, some of the agents have been taken off the market due to cardiovascular toxicity. With that in mind, Clapper says, "If we can find something in the same arena that is effective and nontoxic, it will be extremely valuable."

NO-naproxen and other NO-donating NSAID derivatives are a new class of agents being developed with the aim of reducing gastrointestinal toxicity, a relatively common side effect associated with NSAIDs.

The first author on the study is EunRan Suh. Co-authors include Christina Ferrara, Esther Kaunga, Harry S. Cooper, and Wen-Chi L. Chang of Fox Chase and Ronald A. Lubet of the National Cancer Institute. Funding for the study came from the National Cancer Institute, NIH.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Nitric oxide-donating naproxen can boost colorectal cancer prevention, study suggests." ScienceDaily. ScienceDaily, 21 April 2010. <www.sciencedaily.com/releases/2010/04/100421102340.htm>.
Fox Chase Cancer Center. (2010, April 21). Nitric oxide-donating naproxen can boost colorectal cancer prevention, study suggests. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/04/100421102340.htm
Fox Chase Cancer Center. "Nitric oxide-donating naproxen can boost colorectal cancer prevention, study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/04/100421102340.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins