Featured Research

from universities, journals, and other organizations

Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response

Date:
April 22, 2010
Source:
Libre de Bruxelles, Université
Summary:
Fetuses and infants are highly susceptible to viral infections. A number of viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared to later life. Researchers in Belgium recently found that human fetal gd T cells can mount a vigorous response to CMV infection during development in utero. They discovered a novel anti-CMV gd T cell receptor that was highly expanded in CMV-infected fetuses.

Fetuses and infants are highly susceptible to viral infections. A number of viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared to later life.

Related Articles


CMV is the most common cause of infection of the fetus: about 1 in 100 newborns are infected. Although CMV infection causes no detectable symptoms in immunocompetent adults, about 20% of CMV-infected newborns develop serious symptoms, including cerebral malformations, multiple organ failure, deafness, and mental retardation. It is generally accepted that this increased susceptibility to viral infections is related to the immaturity of the neonatal immune system.

T cells are a part of the cellular immune system that is important to fight viral infections. γδ T cells are unconventional T cells: they do not recognize pieces of pathogen proteins (for example from viruses) as conventional ab T cells do. In fact, it is largely unknown what γδ T cell receptors recognize.

At the Institute for Medical Immunology (Université Libre de Bruxelles), in collaboration with clinicians from Hôpital Erasme and Le Centre Hospitalier Universitaire Saint-Pierre, they have found that human fetal γδ T cells can mount a vigorous response to CMV infection during development in utero. They discovered a novel anti-CMV γδ T cell receptor that was highly expanded in CMV-infected fetuses. Thus γδ T cells can provide an important mechanism by which the fetus fights pathogens and they could be a target for the design of novel vaccination strategies against infection in early life.

This study has been published in The Journal of Experimental Medicine.


Story Source:

The above story is based on materials provided by Libre de Bruxelles, Université. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Vermijlen, M. Brouwer, C. Donner, C. Liesnard, M. Tackoen, M. Van Rysselberge, N. Twite, M. Goldman, A. Marchant, F. Willems. Human cytomegalovirus elicits fetal γδ T cell responses in utero. Journal of Experimental Medicine, 2010; 207 (4): 807 DOI: 10.1084/jem.20090348

Cite This Page:

Libre de Bruxelles, Université. "Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response." ScienceDaily. ScienceDaily, 22 April 2010. <www.sciencedaily.com/releases/2010/04/100422095547.htm>.
Libre de Bruxelles, Université. (2010, April 22). Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2010/04/100422095547.htm
Libre de Bruxelles, Université. "Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response." ScienceDaily. www.sciencedaily.com/releases/2010/04/100422095547.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) — A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com
In Rural Sierra Leone the Red Cross Battles Ebola

In Rural Sierra Leone the Red Cross Battles Ebola

AFP (Dec. 17, 2014) — The Red Cross battles the Ebola virus in rural Sierra Leone and its fallout. In one treatment centre in the city of Kenema, the Red Cross also runs a kindergarten. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins