Featured Research

from universities, journals, and other organizations

Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response

Date:
April 22, 2010
Source:
Libre de Bruxelles, Université
Summary:
Fetuses and infants are highly susceptible to viral infections. A number of viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared to later life. Researchers in Belgium recently found that human fetal gd T cells can mount a vigorous response to CMV infection during development in utero. They discovered a novel anti-CMV gd T cell receptor that was highly expanded in CMV-infected fetuses.

Fetuses and infants are highly susceptible to viral infections. A number of viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared to later life.

CMV is the most common cause of infection of the fetus: about 1 in 100 newborns are infected. Although CMV infection causes no detectable symptoms in immunocompetent adults, about 20% of CMV-infected newborns develop serious symptoms, including cerebral malformations, multiple organ failure, deafness, and mental retardation. It is generally accepted that this increased susceptibility to viral infections is related to the immaturity of the neonatal immune system.

T cells are a part of the cellular immune system that is important to fight viral infections. γδ T cells are unconventional T cells: they do not recognize pieces of pathogen proteins (for example from viruses) as conventional ab T cells do. In fact, it is largely unknown what γδ T cell receptors recognize.

At the Institute for Medical Immunology (Université Libre de Bruxelles), in collaboration with clinicians from Hôpital Erasme and Le Centre Hospitalier Universitaire Saint-Pierre, they have found that human fetal γδ T cells can mount a vigorous response to CMV infection during development in utero. They discovered a novel anti-CMV γδ T cell receptor that was highly expanded in CMV-infected fetuses. Thus γδ T cells can provide an important mechanism by which the fetus fights pathogens and they could be a target for the design of novel vaccination strategies against infection in early life.

This study has been published in The Journal of Experimental Medicine.


Story Source:

The above story is based on materials provided by Libre de Bruxelles, Université. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Vermijlen, M. Brouwer, C. Donner, C. Liesnard, M. Tackoen, M. Van Rysselberge, N. Twite, M. Goldman, A. Marchant, F. Willems. Human cytomegalovirus elicits fetal γδ T cell responses in utero. Journal of Experimental Medicine, 2010; 207 (4): 807 DOI: 10.1084/jem.20090348

Cite This Page:

Libre de Bruxelles, Université. "Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response." ScienceDaily. ScienceDaily, 22 April 2010. <www.sciencedaily.com/releases/2010/04/100422095547.htm>.
Libre de Bruxelles, Université. (2010, April 22). Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/04/100422095547.htm
Libre de Bruxelles, Université. "Fetuses can fight cytomegalovirus (CMV) infection: A novel unconventional immune response." ScienceDaily. www.sciencedaily.com/releases/2010/04/100422095547.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins