Featured Research

from universities, journals, and other organizations

Obese children metabolize drugs differently than healthy weight children

Date:
April 28, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
Researchers have provided the first evidence-based data on changes in drug metabolism in obese children as compared to healthy weight children.

Researchers from the University of Minnesota College of Pharmacy have provided the first evidence-based data on changes in drug metabolism in obese children as compared to healthy weight children.

The study, conducted by L'Aurelle Johnson and Manoj Chiney in the Department of Experimental and Clinical Pharmacy, evaluated drug metabolism in sixteen healthy weight children and nine obese children.

"We have known for years that drugs metabolize differently in obese adults as compared to healthy weight adults," said Johnson. "But, there has been very little, if any, information available that specifically addresses the consequences of obesity on drug metabolism in children. Without this information, our ability to identify optimal drug dosing in children often relies on trial and error approaches."

In the study, Johnson and Chiney examined drug metabolizing enzyme activity in healthy weight and obese children, age 6 to 10 years old. Specifically, they looked at how the children metabolized caffeine and dextromethorphan, a key ingredient in the cough suppressant Robitussinฎ DM.

They found that obese children metabolized both drugs at different rates than healthy weight children.

Johnson said this finding is the first of many steps in determining the overall effect of obesity on drug absorption, distribution, metabolism and elimination in children. She plans to conduct additional research to define the activity of other drug metabolizing enzymes that may also be altered in the pediatric population as a result of obesity.

"Collectively, such knowledge concerning key factors that impact activity of drug metabolizing enzymes in children will have a significant positive impact on the development of optimal drug dosing regiments in children in order to maximize efficacy, while minimizing potential adverse drug effects, in the treatment of serious diseases such as cancer," said Johnson.

Johnson presented the research, which was funded by the NIH National Center for Research Resources "Multidisciplinary Scholar Development Program" 5K12RR023247, at the American Society for Pharmacology and Experimental Therapeutics annual meeting in a poster titled "The effect of obesity on drug metabolism in African-American children."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "Obese children metabolize drugs differently than healthy weight children." ScienceDaily. ScienceDaily, 28 April 2010. <www.sciencedaily.com/releases/2010/04/100427171800.htm>.
Federation of American Societies for Experimental Biology. (2010, April 28). Obese children metabolize drugs differently than healthy weight children. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/04/100427171800.htm
Federation of American Societies for Experimental Biology. "Obese children metabolize drugs differently than healthy weight children." ScienceDaily. www.sciencedaily.com/releases/2010/04/100427171800.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins