Featured Research

from universities, journals, and other organizations

Use of antibiotic by children with cystic fibrosis does not result in improved lung function, study finds

Date:
May 4, 2010
Source:
JAMA and Archives Journals
Summary:
Children and adolescents with cystic fibrosis who received the antibiotic azithromycin did not experience improved lung function, compared to patients who received placebo, according to a new study.

Children and adolescents with cystic fibrosis who received the antibiotic azithromycin did not experience improved lung function, compared to patients who received placebo, according to a study in the May 5 issue of JAMA.

Related Articles


"A vicious cycle of infection and inflammation causes progressive lung destruction and premature death in patients with cystic fibrosis (CF). Treatment strategies have therefore included both antimicrobial and anti-inflammatory agents," the authors write. There has been increasing evidence over the past decade that azithromycin, an antibiotic with both antimicrobial and anti-inflammatory activity, benefits individuals with CF. "Azithromycin is recommended as therapy for CF patients with chronic Pseudomonas aeruginosa [a bacteria] infection, but there has not been sufficient evidence to support the benefit of azithromycin in other patients with CF."

Lisa Saiman, M.D., M.P.H., of Columbia University, New York, and colleagues conducted a ran¬domized, placebo-controlled trial involving children and ado¬lescents with CF who were uninfected with P aeruginosa to determine if azithromycin would improve lung function or reduce pulmonary exacerbations. The trial was conducted from February 2007 to July 2009 at 40 CF care centers in the United States and Canada. Of the 324 participants screened, 260 met study criteria, were randomized and received either the study drug (n = 131) or placebo (n = 129). The average age of the participants was 10.7 years.

The researchers found that treatment with azithromycin for 24 weeks, compared with placebo, did not result in improved pulmonary function, as measured by the change in FEV1 (the volume of air that can be forced out in one second after taking a deep breath). "However, analyses of exploratory end points demonstrated that when compared with the placebo group, the azithromycin group had a 50 percent reduction in pulmonary exacer¬bations, 27 percent reduction in the initia¬tion of new oral antibiotics (other than azithromycin), 1.3 lbs. weight gain, and 0.34-unit increase in body mass index. There were no differences in treatment groups in the use of intravenous or inhaled antibiot¬ics or hospitalizations," the authors write.

Participants in the azithromycin group had less cough and less productive cough, compared with placebo participants.

"Further studies of azithromycin are warranted to further investigate its potential use in this population," the researchers conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lisa Saiman; Michael Anstead; Nicole Mayer-Hamblett; Larry C. Lands; Margaret Kloster; Jasna Hocevar-Trnka; Christopher H. Goss; Lynn M. Rose; Jane L. Burns; Bruce C. Marshall; Felix Ratjen; for the AZ0004 Azithromycin Study Group. Effect of Azithromycin on Pulmonary Function in Patients With Cystic Fibrosis Uninfected With Pseudomonas aeruginosa: A Randomized Controlled Trial. JAMA, 2010; 303 (17): 1707-1715 [link]

Cite This Page:

JAMA and Archives Journals. "Use of antibiotic by children with cystic fibrosis does not result in improved lung function, study finds." ScienceDaily. ScienceDaily, 4 May 2010. <www.sciencedaily.com/releases/2010/05/100504163113.htm>.
JAMA and Archives Journals. (2010, May 4). Use of antibiotic by children with cystic fibrosis does not result in improved lung function, study finds. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2010/05/100504163113.htm
JAMA and Archives Journals. "Use of antibiotic by children with cystic fibrosis does not result in improved lung function, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/05/100504163113.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins