Featured Research

from universities, journals, and other organizations

Survival in metastatic breast cancer directly linked to circulating tumor cells

Date:
May 6, 2010
Source:
European Society for Medical Oncology
Summary:
A new study of metastatic breast cancer shows that the number of circulating tumor cells patients have in their blood directly correlates with the length of their survival.

A new study of metastatic breast cancer shows that the number of circulating tumor cells patients have in their blood directly correlates with the length of their survival. Reported at the IMPAKT Breast Cancer Conference in Brussels, Belgium, the results have the potential to improve the delivery of personalized therapy to these patients.

Circulating tumor cells --cancer cells found in a patient's bloodstream-- are detected in 50% to 80% of patients with metastatic breast cancer. Since 2004, doctors have known that patients with 5 or more of these cells in 7.5 ml of blood survive on average for less time than those with fewer than 5 cells.

Dr Antonio Giordano from MD Anderson Cancer Center in Houston, USA, and colleagues set out to refine this prognostic test using a sophisticated computer model known as an artificial neural network.

"We chose to use an artificial neural network model to analyze 516 consecutive metastatic breast cancer patients at the University of Texas MD Anderson Cancer Center because, unlike more typical statistical methods, it can estimate the complex interactions between different factors over time," said Dr Giordano. "Our model, designed at the University of Naples Federico II, simply represents a dynamic time-related analysis of survival, taking into account all prognostic factor correlations."

Using the artificial neural network, the researchers studied the relationship between increasing numbers of circulating tumor cells and survival for different subgroups of breast cancer.

"We found that there was a linear relationship between the number of circulating tumor cells and the risk of death in patients with metastatic breast cancer. Most importantly, the risk of death after 1 year for patients with 40 circulating tumor cells in 7.5 ml of blood was about twice that for patients with none."

"These results show that the simple cutoff number of 5 circulating tumor cells probably does not adequately represent the complexity of this prognostic variable," Dr Giordano said. "Artificial neural networks are sophisticated techniques for analyzing survival of patients according to continuous variables over time."

Translated to clinical practice, these results suggest that monitoring of circulating tumor cell numbers should now be considered a standard test for patients with metastatic breast cancer, Dr Giordano said.

"While the treatment of this condition remains palliative, monitoring of circulating tumor cells can help determine when to modify regimens or discontinue therapy, in other words, this can improve the delivery of personalized therapy."


Story Source:

The above story is based on materials provided by European Society for Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society for Medical Oncology. "Survival in metastatic breast cancer directly linked to circulating tumor cells." ScienceDaily. ScienceDaily, 6 May 2010. <www.sciencedaily.com/releases/2010/05/100506112601.htm>.
European Society for Medical Oncology. (2010, May 6). Survival in metastatic breast cancer directly linked to circulating tumor cells. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/05/100506112601.htm
European Society for Medical Oncology. "Survival in metastatic breast cancer directly linked to circulating tumor cells." ScienceDaily. www.sciencedaily.com/releases/2010/05/100506112601.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins