Featured Research

from universities, journals, and other organizations

High cholesterol levels affect mobilization of cells from bone marrow: Implications for transplants and understanding cancer onset

Date:
May 10, 2010
Source:
Instituto Gulbenkian de Ciência (IGC)
Summary:
Increased cholesterol levels are being increasingly recognized as risk factors for the onset and progression of several cancers. Now researchers in Portugal show that high levels of cholesterol can affect the microenvironment of the bone marrow, so that more cells move from the bone marrow to peripheral, circulating blood.

Increased cholesterol levels are being increasingly recognised as risk factors for the onset and progression of several cancers. Now researchers in Portugal show that high levels of cholesterol can affect the microenvironment of the bone marrow, so that more cells move from the bone marrow to peripheral, circulating blood.

Related Articles


These findings, by Sergio Dias and his team, an external group of the Instituto Gulbenkian de Ciência, have implications for transplantation and further understanding bone marrow malignancies, are to appear in the next issue of the journal Blood.

Progenitors of blood cells develop in the bone marrow, where they mature in specific microenvironments, called niches, before exiting into peripheral blood, in a highly controlled fashion. It is well established that external stimuli affect these niches and therefore the production of mature blood cells. For example, patients with high cholesterol levels (hypercholesterolemia) have more peripheral blood cells and increased platelet levels (thrombocytosis). Working at the Portuguese Institute of Oncology Francisco Gentil, in Lisbon, the Neoangiogenesis group used a mouse model of hypercholesterolemia to show that cholesterol interferes with the bone marrow niche equilibrium, thus leading to increased exit from the bone marrow niche to the peripheral circulation.

These finding may have implications for transplants and bone marrow malignances. As Sérgio Dias points out "It is the first time, as far as we are aware, that cholesterol is directly linked to mobilisation of cells in the bone marrow. In a transplant setting, we believe patients with high cholesterol may be less 'receptive', since more blood cells exit to the peripheral vessels. Therefore drugs that modulate cholesterol levels may have beneficial effects also in a transplant setting."

"Furthermore, as cholesterol empties cells from the bone marrow microenvironment, we envisage that it may create more space for malignant leukaemia cells to come into the bone marrow, thus favoring acute leukaemia expansion and spread to secondary organs," this group leader adds.

This study was carried out with support from the Portuguese national funding agency, Fundação para a Ciência e a Tecnologia (FCT) and GlaxoSmithKline.


Story Source:

The above story is based on materials provided by Instituto Gulbenkian de Ciência (IGC). Note: Materials may be edited for content and length.


Journal Reference:

  1. A. L. Gomes, T. Carvalho, J. Serpa, C. Torre, S. Dias. Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF1:CXCR4 axis. Blood, 2009; DOI: 10.1182/blood-2009-08-240580

Cite This Page:

Instituto Gulbenkian de Ciência (IGC). "High cholesterol levels affect mobilization of cells from bone marrow: Implications for transplants and understanding cancer onset." ScienceDaily. ScienceDaily, 10 May 2010. <www.sciencedaily.com/releases/2010/05/100510092515.htm>.
Instituto Gulbenkian de Ciência (IGC). (2010, May 10). High cholesterol levels affect mobilization of cells from bone marrow: Implications for transplants and understanding cancer onset. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2010/05/100510092515.htm
Instituto Gulbenkian de Ciência (IGC). "High cholesterol levels affect mobilization of cells from bone marrow: Implications for transplants and understanding cancer onset." ScienceDaily. www.sciencedaily.com/releases/2010/05/100510092515.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) — A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) — Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins