Featured Research

from universities, journals, and other organizations

Drug in new class of targeted therapies shows early promise against blood-related cancers

Date:
May 20, 2010
Source:
John Theurer Cancer Center
Summary:
A Phase I clinical trial of SNS-032, one of the first in a new class of drugs that inhibit cyclin-dependent kinases, demonstrated the drug's safety and potential clinical action against advanced chronic lymphocytic leukemia.

A Phase I clinical trial of SNS-032, one of the first in a new class of drugs that inhibit cyclin-dependent kinases, demonstrated the drug's safety and potential clinical action against advanced chronic lymphocytic leukemia (CLL). Cyclin-dependent kinases are enzymatic proteins that are integrally involved in cellular metabolism, renewal and signaling, and are thought to play key roles in the growth of cancers. The drug did not demonstrate any clinical effect against advanced multiple myeloma, although researchers hope it might still prove to have some benefit against this blood cancer as part of combination therapy. The paper is published online in the Journal of Clinical Oncology.

"No drugs that target this cancer mechanism are on the market today," says study author David S. Siegel, M.D., Ph.D., Co-Chief, Multiple Myeloma, John Theurer Cancer Center at Hackensack University Medical Center. "I am hopeful that larger studies will show that this targeted therapy is useful against a number of advanced B cell malignancies."

Chronic lymphocytic leukemia (CLL) and multiple myeloma are both considered B cell malignancies, as they attack these cells, also known as B lymphocytes. B lymphocytes are white blood cells that develop in the bone marrow and make antibodies that protect the immune system. Both types of blood cancer leave their victims susceptible to infections and other serious complications. While there are treatments for both cancers, there is no cure, and more effective treatments are needed.

"At the John Theurer Cancer Center we are committed to exploring new treatment options for rare cancers, such as multiple myeloma and CLL," said Andrew L. Pecora, M.D., F.A.C.P., C.P.E., Chairman and Executive Administrative Director, John Theurer Cancer Center. "We will continue to research new therapies to help our patients live longer and to find a cure for these diseases."

Dr. Siegel and colleagues tested the new medication on 37 patients, 19 with CLL and 18 with myeloma. Patients recruited to the study had advanced disease that was in relapse, and all had been through previous treatments with other medications (median number of prior treatments: four). All patients were given SNS-032, and all were aware of what they were taking.

To test both the drug's safety and the best potential dose, SNS-032 was given intravenously as a "loading" dose -- an initially higher dose that is then reduced to a maintenance level -- over five minutes. This was followed by a six-hour infusion given to all patients on a weekly basis for three consecutive weeks.

Although the primary purpose of the study was to test the maximum safe dose that could be given to patients, Dr. Siegel and colleagues also looked at whether the medication had an effect on disease processes. One patient with CLL had more than a 50 percent reduction in measurable disease, but no improvement in disease markers in the blood. Another CLL patient had stable disease for four courses of treatment. For multiple myeloma, two patients had stable disease with treatment and one had normalization of spleen size, which is an indication of a reduction in blood cancer activity.

Looking at blood test results for the patients, the researchers found anti-cancer activity. The drug appeared to inhibit cyclin-dependent kinases 7 and 9, two of the three enzymatic proteins targeted in this study. They also caused apoptosis, or cell death, in cancer cells.

"Our study found that this drug is well tolerated and had some clinical effect, but it is important to note that this was a small, very early stage study," says Dr. Siegel. "Based on these findings, there is justification for additional research, which will show whether this drug has a place in the arsenal of treatments for hematologic malignancies."

Preclinical studies of SNS-032 demonstrated that the drug inhibited the growth of cancer cells, and induced apoptosis, in B cell malignancies.

"The results of the preclinical studies suggest that we might see more anti-tumor effects if the drug is given over a longer period, possibly eight hours or more," adds Dr. Siegel. "Because the patients in the study were at a late disease stage and heavily pretreated, we might also see more of a response in earlier-stage patients. Future studies could look at these issues, as well as the feasibility of using SNS-032 in combination with other therapies."

Researchers from the University of Texas M.D. Anderson Cancer Center, Emory University, University of Maryland, City of Hope, Stanford University, and Sunesis Pharmaceuticals also contributed to this study.


Story Source:

The above story is based on materials provided by John Theurer Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. G. Tong, R. Chen, W. Plunkett, D. Siegel, R. Sinha, R. D. Harvey, A. Z. Badros, L. Popplewell, S. Coutre, J. A. Fox, K. Mahadocon, T. Chen, P. Kegley, U. Hoch, W. G. Wierda. Phase I and Pharmacologic Study of SNS-032, a Potentand Selective Cdk2, 7, and 9 Inhibitor, in Patients With Advanced Chronic Lymphocytic Leukemia andMultiple Myeloma. Journal of Clinical Oncology, 2010; DOI: 10.1200/JCO.2009.26.1347

Cite This Page:

John Theurer Cancer Center. "Drug in new class of targeted therapies shows early promise against blood-related cancers." ScienceDaily. ScienceDaily, 20 May 2010. <www.sciencedaily.com/releases/2010/05/100519112719.htm>.
John Theurer Cancer Center. (2010, May 20). Drug in new class of targeted therapies shows early promise against blood-related cancers. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2010/05/100519112719.htm
John Theurer Cancer Center. "Drug in new class of targeted therapies shows early promise against blood-related cancers." ScienceDaily. www.sciencedaily.com/releases/2010/05/100519112719.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins