Featured Research

from universities, journals, and other organizations

Disagreement on symptom-reflux association analysis parameters in infants

Date:
May 20, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Switzerland and Germany assessed the agreement within three commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. The three SAA parameters showed an important disagreement, thus putting the diagnostic accuracy of SAA for the diagnosis of GERD into question.

Gastroesophageal reflux (GER), defined as passage of gastric contents into the esophagus is a normal process that occurs in healthy infants, children and adults. When GER causes troublesome symptoms and/or complications it is referred to as gastroesophageal reflux disease (GERD). During infancy, GER is common and can manifest with specific symptoms as vomiting and non-specific symptoms as irritability and cough.

Association of non-specific symptoms with GER is a main problem in the diagnosis of GERD. Timely association of GER episodes and symptom episodes are expressed by symptom-reflux association analysis (SAA) parameters. Abnormal results of SAA parameters point towards GERD. Three SAA parameters are commonly used, symptom index (SI), symptom sensitivity index (SSI) and symptom association probability (SAP). The agreement of these 3 SAA parameters has never been investigated in the infant population.

A research article to be published on May 21, 2010 in the World Journal of Gastroenterology addresses this question. A research team led by Professor Samuel C Lüthold, investigated infants with suspected GERD presenting with irritability and cough, using combined pH/MII monitoring.

Evaluating the irritability-GER association, SI, SSI and SAP showed a non-identical classification in almost 40% of infants. Evaluating the cough-GER association SI, SSI and SAP showed a non-identical classification in over 50% of infants. The study showed that the results of SI, SSI and SAP for the diagnosis of GERD often differ. In consequence, the diagnosis of GERD in infants cannot be based on a single SAA parameter as it remains unknown which SAA parameter is the most accurate for the diagnosis of GERD.

The authors suggest that the diagnosis of GERD should be based on a combination of pH/MII-monitoring, SAA results as well as on other factors such as clinical judgment, gastroscopy and follow-up under medical therapy. Validation studies to enhance the accuracy of SAA parameters and to answer the question which SAA parameter is the most accurate are needed.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lüthold SC, Rochat MK, Bähler P. Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation. World Journal of Gastroenterology, 2010; 16 (19): 2401 DOI: 10.3748/wjg.v16.i19.2401

Cite This Page:

World Journal of Gastroenterology. "Disagreement on symptom-reflux association analysis parameters in infants." ScienceDaily. ScienceDaily, 20 May 2010. <www.sciencedaily.com/releases/2010/05/100520112351.htm>.
World Journal of Gastroenterology. (2010, May 20). Disagreement on symptom-reflux association analysis parameters in infants. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/05/100520112351.htm
World Journal of Gastroenterology. "Disagreement on symptom-reflux association analysis parameters in infants." ScienceDaily. www.sciencedaily.com/releases/2010/05/100520112351.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins