Featured Research

from universities, journals, and other organizations

Disagreement on symptom-reflux association analysis parameters in infants

Date:
May 20, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Switzerland and Germany assessed the agreement within three commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. The three SAA parameters showed an important disagreement, thus putting the diagnostic accuracy of SAA for the diagnosis of GERD into question.

Gastroesophageal reflux (GER), defined as passage of gastric contents into the esophagus is a normal process that occurs in healthy infants, children and adults. When GER causes troublesome symptoms and/or complications it is referred to as gastroesophageal reflux disease (GERD). During infancy, GER is common and can manifest with specific symptoms as vomiting and non-specific symptoms as irritability and cough.

Related Articles


Association of non-specific symptoms with GER is a main problem in the diagnosis of GERD. Timely association of GER episodes and symptom episodes are expressed by symptom-reflux association analysis (SAA) parameters. Abnormal results of SAA parameters point towards GERD. Three SAA parameters are commonly used, symptom index (SI), symptom sensitivity index (SSI) and symptom association probability (SAP). The agreement of these 3 SAA parameters has never been investigated in the infant population.

A research article to be published on May 21, 2010 in the World Journal of Gastroenterology addresses this question. A research team led by Professor Samuel C Lüthold, investigated infants with suspected GERD presenting with irritability and cough, using combined pH/MII monitoring.

Evaluating the irritability-GER association, SI, SSI and SAP showed a non-identical classification in almost 40% of infants. Evaluating the cough-GER association SI, SSI and SAP showed a non-identical classification in over 50% of infants. The study showed that the results of SI, SSI and SAP for the diagnosis of GERD often differ. In consequence, the diagnosis of GERD in infants cannot be based on a single SAA parameter as it remains unknown which SAA parameter is the most accurate for the diagnosis of GERD.

The authors suggest that the diagnosis of GERD should be based on a combination of pH/MII-monitoring, SAA results as well as on other factors such as clinical judgment, gastroscopy and follow-up under medical therapy. Validation studies to enhance the accuracy of SAA parameters and to answer the question which SAA parameter is the most accurate are needed.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lüthold SC, Rochat MK, Bähler P. Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation. World Journal of Gastroenterology, 2010; 16 (19): 2401 DOI: 10.3748/wjg.v16.i19.2401

Cite This Page:

World Journal of Gastroenterology. "Disagreement on symptom-reflux association analysis parameters in infants." ScienceDaily. ScienceDaily, 20 May 2010. <www.sciencedaily.com/releases/2010/05/100520112351.htm>.
World Journal of Gastroenterology. (2010, May 20). Disagreement on symptom-reflux association analysis parameters in infants. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2010/05/100520112351.htm
World Journal of Gastroenterology. "Disagreement on symptom-reflux association analysis parameters in infants." ScienceDaily. www.sciencedaily.com/releases/2010/05/100520112351.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) — Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) — The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) — The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) — Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins