Featured Research

from universities, journals, and other organizations

Kidney weight matters when it comes to transplantation

Date:
May 22, 2010
Source:
American Society of Nephrology
Summary:
Receiving an organ low in weight in relation to the recipient's body weight increases kidney transplant recipients risk of complications and transplant failure, according to a new study. The results suggest that compatibility between a donated kidney's weight and the weight of the recipient could improve the success of transplantation.

Receiving an organ low in weight in relation to the recipient's body weight increases kidney transplant recipients risk of complications and transplant failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results suggest that compatibility between a donated kidney's weight and the weight of the recipient could improve the success of transplantation.

Few studies have examined the direct impact of matching a donated kidney's weight to the weight of a transplant recipient. To investigate, Professor Jean Paul Soulillou (Institut National de la Santé Et de la Recherche Médicale (INSERM) Unité 643 and Institut de Transplantation Et de Recherche en Transplantation (ITERT), in Nantes, France) and his colleagues studied how kidney weight to recipient weight ratios affect the long-term kidney health of individuals who receive transplants.

After following 1189 patients for an average of 6.2 years after transplantation, the investigators found that the greater the incompatibilities of weight ratios, the more likely patients were to develop kidney problems. Specifically, a low kidney weight to recipient weight ratio (< 2.3 g/kg) increased the risk of developing inadequate kidney filtration, excess urinary protein excretion, hypertension, kidney scarring, and transplant failure. This low kidney weight to recipient weight ratio was associated with a 55% increased risk of transplant failure after two years of follow-up.

"This information is potentially useful for thousands of transplantations and provides a new opportunity to improve long-term graft survival," said Professor Soulillou. He added that the clinical impact of the kidney weight to recipient weight ratio is similar to what was described decades ago for human leukocyte antigens, which are the major compatibility markers used today to determine transplant-recipient matches.

Study co-authors include Magali Giral, MD, PhD, Yohann Foucher, PhD, Georges Karam, MD, Yann Labrune, Pascal Daguin (ITERT); Michèle Kessler, MD (Centre Hospitalier Universitaire de Brabois); Bruno Hurault de Ligny, MD (Centre Hospitalier Universitaire de Clemenceau); Mathias Büchler, MD, PhD (Centre Hospitalier Universitaire de Bretonneau); François Bayle, MD (Centre Hospitalier Universitaire de Grenoble); Carole Meyer, MD (Centre Hospitalier Universitaire de Strasbourg); Nathalie Trehet, Karine Renaudin, MD, and Anne Moreau, MD (Centre Hospitalier Universitaire de Nantes).

In reviewing the results of Professor Soulillou's study in an accompanying editorial, Ron Shapiro, MD (University of Pittsburgh) stated that "the authors are to be congratulated for describing a novel measure that may have important implications for long-term outcomes in renal allograft recipients." He noted, however, that because living donors made up less than 1% of the study's cases, it is not clear if the findings hold true for recipients other than those who receive deceased donor kidneys.

Also, Dr. Shapiro noted that kidneys from very young pediatric donors might be associated with different outcomes, particularly if two kidneys from one child are transplanted into an adult, as is commonly done). According to a 2009 study in the Clinical Journal of the American Society of Nephrology (CJASN), a single kidney from a very young deceased donor maintains the health of an adult with kidney failure. Other studies have reported more complications when single kidneys from very young donors are transplanted into adults.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal References:

  1. Magali Giral, Yohann Foucher, Georges Karam, Yann Labrune, Michelle Kessler, Bruno Hurault de Ligny, Mathias Büchler, François Bayle, Carole Meyer, Nathalie Trehet, Pascal Daguin, Karine Renaudin, Anne Moreau, and Jean Paul Soulillou. Kidney and Recipient Weight Incompatibility Reduces Long-Term Graft Survival. Journal of the American Society Nephrology, 2010; DOI: 10.1681/ASN.2009121296
  2. Ron Shapiro. Size Matters in Renal Allograft Survival. Journal of the American Society Nephrology, 2010; DOI: 10.1681/ASN.2010040380
  3. R. Zhang, A. Paramesh, S. Florman, C. L. Yau, S. Balamuthusamy, N. K. Krane, D. Slakey. Long-Term Outcome of Adults Who Undergo Transplantation with Single Pediatric Kidneys: How Young Is too Young? Clinical Journal of the American Society of Nephrology, 2009; 4 (9): 1500 DOI: 10.2215/CJN.04610908

Cite This Page:

American Society of Nephrology. "Kidney weight matters when it comes to transplantation." ScienceDaily. ScienceDaily, 22 May 2010. <www.sciencedaily.com/releases/2010/05/100520212617.htm>.
American Society of Nephrology. (2010, May 22). Kidney weight matters when it comes to transplantation. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2010/05/100520212617.htm
American Society of Nephrology. "Kidney weight matters when it comes to transplantation." ScienceDaily. www.sciencedaily.com/releases/2010/05/100520212617.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins