Featured Research

from universities, journals, and other organizations

Bone marrow plays critical role in enhancing immune response to viruses, researchers find

Date:
June 1, 2010
Source:
The Mount Sinai Hospital / Mount Sinai School of Medicine
Summary:
Researchers for the first time have determined that bone marrow cells play a critical role in fighting respiratory viruses, making the bone marrow a potential therapeutic target, especially in people with compromised immune systems. They have found that during infections of the respiratory tract, cells produced by the bone marrow are instructed by proteins to migrate to the lungs to help fight infection.

Researchers at Mount Sinai School of Medicine for the first time have determined that bone marrow cells play a critical role in fighting respiratory viruses, making the bone marrow a potential therapeutic target, especially in people with compromised immune systems. They have found that during infections of the respiratory tract, cells produced by the bone marrow are instructed by proteins to migrate to the lungs to help fight infection.

The data are published in the current issue of Cell Host & Microbe.

Led by Carolina Lopez, PhD, Assistant Professor of Microbiology at Mount Sinai School of Medicine, the research team evaluated the immune response to influenza infection in the lung and blood of mice. The team found that in the days following infection the lung became inflamed and produced interferons, or infection-fighting proteins, a message that alerted bone marrow cells of the presence of the virus and signaled them to prepare to fight the infection. The researchers determined that many new cells generated in the bone marrow enter the infected lung to help fight infection.

Previous studies of the immune response against respiratory viruses focused on the regulation of specific immune cells that acquire a specific function in the lymph nodes of the infected animals. These adaptive cells develop relatively late during infection, but are important for the clearance of the virus and for protection against reinfection with the same virus. This study is the first to show that the immune response also involves the earlier activation of cells in the bone marrow, and that this earlier response is also critical for the efficient clearance of the virus.

"Our research shows that in addition to the regulation of the development of cells, the immune response is regulated at a much earlier stage by influencing cells in the distal bone marrow and that this regulation of what is known as the innate immune response is important for the efficient clearance of the infection," said Dr. Lopez. "Very limited research has been done to evaluate bone marrow's response to a virus infection. Our study is the first to determine the pivotal role bone marrow cells play in fighting a respiratory infection. This discovery has broad-reaching implications in boosting protection against viruses."

After the mice were infected, researchers analyzed the inflammatory response daily by measuring the level of immune cells present in the lung, blood and bone marrow. They noticed that interferons, or anti-viral proteins, and cytokines, a type of immune cell, were produced exclusively by the infected lung but cells in the bone marrow responded to the infection with the expression of a number of anti-viral proteins known to be induced by interferons. Further analysis showed that cells from the bone marrow of infected mice were protected from the virus and were able to produce higher levels of cytokines upon exposure to a virus. The analysis showed that the bone marrow supplies the lung with infection-fighting cells, and that acute infection of the lung is sensed by bone marrow cells, cuing them to be prepared to fight the virus.

"The findings may be especially significant for people with compromised immune systems, including transplant and HIV patients," said Dr. Lopez. "These patients are treated with anti-viral drugs to help them avoid infection or reactivation of chronic viruses, as these types of infections are especially dangerous and could become systemic in people with suppressed immune systems. This new discovery may open new avenues for prevention and treatment of lethal infections."


Story Source:

The above story is based on materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tamar Hermesh, Bruno Moltedo, Thomas M. Moran, Carolina B. López. Antiviral Instruction of Bone Marrow Leukocytes during Respiratory Viral Infections. Cell Host & Microbe, 2010; 7 (5): 343-353 DOI: 10.1016/j.chom.2010.04.006

Cite This Page:

The Mount Sinai Hospital / Mount Sinai School of Medicine. "Bone marrow plays critical role in enhancing immune response to viruses, researchers find." ScienceDaily. ScienceDaily, 1 June 2010. <www.sciencedaily.com/releases/2010/05/100524143423.htm>.
The Mount Sinai Hospital / Mount Sinai School of Medicine. (2010, June 1). Bone marrow plays critical role in enhancing immune response to viruses, researchers find. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/05/100524143423.htm
The Mount Sinai Hospital / Mount Sinai School of Medicine. "Bone marrow plays critical role in enhancing immune response to viruses, researchers find." ScienceDaily. www.sciencedaily.com/releases/2010/05/100524143423.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) — The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) — The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) — The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) — In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins