Featured Research

from universities, journals, and other organizations

Understanding the relationship between bacteria and obesity

Date:
May 30, 2010
Source:
American Society for Microbiology
Summary:
Research sheds new light on the role bacteria in the digestive tract may play in obesity. The studies paint a picture that may be more complex than originally thought.

Research sheds new light on the role bacteria in the digestive tract may play in obesity. The studies, which were presented at the 110th General Meeting of the American Society for Microbiology, paint a picture that may be more complex than originally thought.

Related Articles


"Work currently underway suggests that an interaction between genetic factors and the composition of the bacteria that inhabit the human gut may predispose certain individuals towards obesity. These results potentially provide insight into the mechanisms by which genetics may predispose some people to obesity. They could also help pave the way towards a future in which genetic screening in conjunction with individually tailored treatments could help people at risk for obesity to maintain a healthy weight," says Margaret Zupancic, of the Institute for Genome Sciences at the University of Maryland School of Medicine, who presented one of the studies.

Zupancic and her colleagues analyzed the gut bacterial communities of lean and obese individuals belonging to the Old Order Amish of Lancaster County, Pennsylvania -- a population relatively homogenous in regard to both genetics and lifestyle. Initially they found no correlation between the composition of the gut bacteria and obesity, but when they factored in the genetic makeup of the participants, certain patterns began to emerge.

One pattern was a statistically significant correlation between whether the participant carried a given variant of the FTO gene (a gene associated with obesity) and the presence of certain bacterial groups in the digestive tract.

The researchers also found that in people with certain genetic variations in taste receptor genes, a low level of bacterial diversity in the gut correlated with a higher likelihood of obesity, while a high level of diversity correlated with a lower likelihood of obesity.

"While this work is still at a relatively early stage, results such as these could lead to applications such as probiotic or antibiotic-based treatments for obesity that could be individualized based on a person's unique genetic and gut microbial makeup," says Zupancic.

Another study from the Fred Hutchinson Cancer Research Center analyzed the gut microbes of women between 40 and 45 years of age. The researchers found a positive correlation between the population of one specific type of bacteria, Bacteroidetes, and body fat percentage in the participants.

Not all research presented at the meeting found differences in bacterial populations in the gut and obesity. One study, focusing specifically on children and childhood obesity, failed to identify any significant differences in the gut microbial communities of obese and normal-weight children.

The researchers subsequently analyzed the ability of the microbes to extract and convert dietary energy. They found higher levels of short-chain fatty acids in the feces of obese children.

"This suggests that although obese and normal-weight children have similar gut microbial communities, the gut microbes in obese children are more efficient at converting dietary substrates into energy," says Amanda Payne of the Institute of Food Health and Nutrition ETH, Zurich, Switzerland.

Short-chain fatty acids are converted into triglycerides and glucose by the liver, a process estimated to provide an additional 10% of dietary energy. The increased production of short-chain fatty acids by gut microbes in obese children could potentially supply more dietary energy, resulting in weight gain.

"While the importance of a balanced diet and regular exercise should not be discounted, our results may help contribute to the development of novel approaches in treating childhood obesity by modulating the composition and activity of the gut microbiota in order to reduce energy extraction from undigested food," says Payne.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Understanding the relationship between bacteria and obesity." ScienceDaily. ScienceDaily, 30 May 2010. <www.sciencedaily.com/releases/2010/05/100526141845.htm>.
American Society for Microbiology. (2010, May 30). Understanding the relationship between bacteria and obesity. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/05/100526141845.htm
American Society for Microbiology. "Understanding the relationship between bacteria and obesity." ScienceDaily. www.sciencedaily.com/releases/2010/05/100526141845.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins