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Protecting nerve cells the job of the protein NFI-A

Date:
June 1, 2010
Source:
Journal of Clinical Investigation
Summary:
Researchers have now identified the gene regulatory protein NFI-A as a new molecular regulator of nerve cell protection in mice. Such information has implications for developing therapeutics that could provide protection against nerve cell death due to neurologic disorders and stroke.

A team of researchers, led by Valina Dawson and Ted Dawson, at Johns Hopkins University School of Medicine, Baltimore, has now identified the gene regulatory protein NFI-A as a new molecular regulator of nerve cell protection in mice. Such information has implications for developing therapeutics that could provide protection against nerve cell death due to neurologic disorders and stroke.

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Sublethal doses of the molecule NMDA induce nerve cells to trigger a molecular survival program. NFI-A is one protein upregulated in this context, but its role in nerve cell survival had not been determined. In this study, knocking down NFI-A induction in mouse nerve cells substantially reduced the neuroprotective effects of sublethal doses of NMDA, indicating a role in the molecular survival program triggered by sublethal doses of NMDA. Several other lines of evidence supported this conclusion and even indicated that NFI-A was required for the protective effects of sublethal doses of NMDA.

These data, define NFI-A as a gene regulatory protein central to nerve cell protection.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sika Zheng, Stephen M. Eacker, Suk Jin Hong, Richard M. Gronostajski, Ted M. Dawson, and Valina L. Dawson. NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI33144

Cite This Page:

Journal of Clinical Investigation. "Protecting nerve cells the job of the protein NFI-A." ScienceDaily. ScienceDaily, 1 June 2010. <www.sciencedaily.com/releases/2010/06/100601124121.htm>.
Journal of Clinical Investigation. (2010, June 1). Protecting nerve cells the job of the protein NFI-A. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/06/100601124121.htm
Journal of Clinical Investigation. "Protecting nerve cells the job of the protein NFI-A." ScienceDaily. www.sciencedaily.com/releases/2010/06/100601124121.htm (accessed October 25, 2014).

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