Featured Research

from universities, journals, and other organizations

Use of local anesthetics in the treatment of inflammatory bowel disease?

Date:
June 2, 2010
Source:
World Journal of Gastroenterology
Summary:
Inflammatory bowel disease (IBD) is a chronic disease of the intestines and no definitive medical treatment has been defined yet. A research team from Turkey applied local anesthetics onto the experimentally induced colitis areas in rats to investigate their potential effect on treating the inflammation at the disease site. The improvement in the macroscopic inflammation at the site of application suggested that local anesthetics might have beneficial therapeutic effects on IBD.

Inflammatory bowel disease (IBD) is a disease of the gastrointestinal tract, mainly the intestines that may occur in the people who have genetic potential with a contribution of environmental factors. There has been no definitive medical treatment and drugs usually help the symptoms just to relieve.

Related Articles


Local anesthetics are used to locally desensitize the tissues to allow surgical interventions. However, their mechanism of action is based on their potential to inhibit neuronal activity in the area. Since it is proposed that IBD may be a result of imbalance in the autonomic neurons of the colon, local anesthetics have the potential to reduce the inflammation at the site of the colon that are affected by IBD.

A research article to be published on May 28, 2010 in the World Journal of Gastroenterology addresses this question. In a recent experimental study, investigators from Uludag University School of Medicine, Bursa, Turkey investigated the possible therapeutic effects of local anesthetics on IBD. They topically applied levobupivacaine, which is a novel, long lasting local anesthetic with less systemic side effects onto the colonic mucosa of the rats that had had experimentally induced IBD.

The researchers used some scoring systems that evaluated the inflammation at the site of drug application. They compared the local anesthetics to saline solution. They found some improvement in the degree of macroscopic inflammation at the areas where local anesthetics were applied; however, those findings were not supported by microscopic findings. Nevertheless, researchers concluded that local anesthetics might have potential therapeutic effects on IBD based on their findings.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Duman U, Yilmazlar A, Ozturk E, Aker S, Sarandol E, Yilmazlar T. Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model. World Journal of Gastroenterology, 2010; 16 (20): 2537 DOI: 10.3748/wjg.v16.i20.2537

Cite This Page:

World Journal of Gastroenterology. "Use of local anesthetics in the treatment of inflammatory bowel disease?." ScienceDaily. ScienceDaily, 2 June 2010. <www.sciencedaily.com/releases/2010/06/100602094511.htm>.
World Journal of Gastroenterology. (2010, June 2). Use of local anesthetics in the treatment of inflammatory bowel disease?. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/06/100602094511.htm
World Journal of Gastroenterology. "Use of local anesthetics in the treatment of inflammatory bowel disease?." ScienceDaily. www.sciencedaily.com/releases/2010/06/100602094511.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins