Featured Research

from universities, journals, and other organizations

Use of testosterone for 'male menopause' questionable, experts argue

Date:
June 16, 2010
Source:
BMJ-British Medical Journal
Summary:
The use of synthetic testosterone to combat symptoms of the so-called "male menopause" is questionable, given that it's not clear whether such a syndrome exists, and that the evidence of the hormone's effectiveness in these circumstances is inconclusive, says a new article.

The use of synthetic testosterone to combat symptoms of the so-called "male menopause" is questionable, given that it's not clear whether such a syndrome exists, and that the evidence of the hormone's effectiveness in these circumstances is inconclusive, says the Drug and Therapeutics Bulletin (DTB).

Related Articles


Unlike the menopause in women, where levels of the female hormone oestrogen plummet and production stops almost completely, in general, testosterone levels fall by only around 1 to 2% a year from the age of 40 onwards in men and production of the hormone does not stop, says DTB.

Low levels of testosterone are not an inevitable consequence of ageing, it says: around 80% of 60 year olds and half of those in their 80s still have levels within the normal range for younger men.

Low testosterone levels in older men do not necessarily produce symptoms. And symptoms sometimes attributed to low hormone levels, such as low sex drive, erection problems, diminished strength, and low mood, occur in many men with normal testosterone levels.

Overall, the evidence that an age-related reduction in testosterone levels causes specific symptoms is weak, says DTB.

These facts undermine the idea that some men develop a condition called late-onset hypogonadism, sometimes known as the "male menopause" or "andropause," it says.

The published evidence is also inconclusive on whether testosterone given to ageing men with low levels of the hormone improves symptoms, such as poor sexual function or depression.

And while there is some suggestion that it modestly increases bone density and muscle strength, whether such effects translate into worthwhile benefits, such as reduced risk of bone fractures, has not been proved.

Testosterone treatment also has several unwanted side effects, says DTB. These include a rise in prostate specific antigen (PSA), blockage of the urinary tract, development of prostate cancer and the development of breasts (gynaecomastia). And it can aggravate ischaemic heart disease, epilepsy, and sleep apnoea.

There are potential issues associated with the different ways of administering testosterone. For example, patches can irritate the skin; implants require minor surgery, which carries risks; and gels can be inadvertently transferred to other people.

Overall, DTB sees only very limited scope for treating men with testosterone who have low levels of the hormone related to age.

"Clinicians should not offer testosterone therapy without explicit discussion of the uncertainty about its risks and benefits in this population," it says.

And it concludes: "There is no place for testosterone therapy in older men without symptoms, or without clearly low testosterone concentrations on more than one occasion."


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Use of testosterone for 'male menopause' questionable, experts argue." ScienceDaily. ScienceDaily, 16 June 2010. <www.sciencedaily.com/releases/2010/06/100602193318.htm>.
BMJ-British Medical Journal. (2010, June 16). Use of testosterone for 'male menopause' questionable, experts argue. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2010/06/100602193318.htm
BMJ-British Medical Journal. "Use of testosterone for 'male menopause' questionable, experts argue." ScienceDaily. www.sciencedaily.com/releases/2010/06/100602193318.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins