Featured Research

from universities, journals, and other organizations

Molecular imaging 'probes' pinpoint prostate cancer

Date:
June 14, 2010
Source:
Society of Nuclear Medicine
Summary:
Molecular imaging has a powerful new weapon in the fight against prostate cancer. Research demonstrates how a novel peptide-targeted imaging agent could help clinicians detect a biological process that signals cancer in prostate cells. Information gathered about this process may even differentiate prostate tumor types and the progression of disease.

Molecular imaging has a powerful new weapon in the fight against prostate cancer. Research introduced at the Society of Nuclear Medicine's 57th Annual Meeting demonstrates how a novel peptide-targeted imaging agent could help clinicians detect a biological process that signals cancer in prostate cells. Information gathered about this process may even differentiate prostate tumor types and the progression of disease.

"This new molecular imaging tool will help us develop new diagnostic and therapeutic options for prostate cancer patients," said Chiun-Wei Huang, Ph.D. candidate, lead author and researcher at the Molecular Imaging Center of the Keck School of Medicine, University of Southern California, Los Angeles, Calif. "By identifying a signature on the cell-surface of specific tumor types at different stages, we could potentially develop better and more customized treatments for truly personalized medicine."

In this study, researchers used near-infrared fluorescent imaging, an optical imaging technique that images the low-frequency light emitted from an imaging agent containing fluorescent dye. The novel agent used in the study was prepared with a peptide that targets receptor activity involved in the prolific growth of certain tumor cells. This specific sequence of receptor activity is called α2β1 integrin, an expression of building-block proteins such as collagen. Cells that display an abnormal over-abundance of this activity could be cancerous, and imaging that focuses on this biological process could provide essential information about the aggressive growth, survival, migration and invasiveness of individual cases of prostate cancer.

Results of the study showed that high absorption of the peptide-targeted agent positively identified prostate tumors both in the laboratory and in three prostate tumor-bearing models. Further development of this and similar imaging agents could lead to more effective and detailed diagnosis of prostate cancer and could be used to test the effectiveness of new drug therapies to treat the disease.

According to the American Cancer Society, prostate cancer is the leading cancer diagnosis in men besides skin cancer. About 1 in 6 men are expected to be diagnosed with prostate cancer at some point in their lives. More than 192,000 men in America were estimated to be diagnosed with prostate cancer in 2009, and 27,360 deaths were projected as a result of the disease.

Scientific Paper 4: C. Huang, Z. Li, H. Cai, A.H. Shahinian, P.S. Conti, University of Southern California, Los Angeles, Calif., "Near-infrared fluorescent imaging of prostate cancer using integrin α2β1 targeted peptide probes," SNM's 57th Annual Meeting, June 5-9, 2010, Salt Lake City, Utah.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "Molecular imaging 'probes' pinpoint prostate cancer." ScienceDaily. ScienceDaily, 14 June 2010. <www.sciencedaily.com/releases/2010/06/100607142011.htm>.
Society of Nuclear Medicine. (2010, June 14). Molecular imaging 'probes' pinpoint prostate cancer. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/06/100607142011.htm
Society of Nuclear Medicine. "Molecular imaging 'probes' pinpoint prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607142011.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins