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Delayed arrival of TB-fighting T cells

Date:
June 14, 2010
Source:
Rockefeller University Press
Summary:
The outcome of tuberculosis infection in mice depends in part on how quickly bacteria-fighting T cells can get to the lungs. According to a new study, another group of T cells delays their arrival.
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The outcome of tuberculosis infection in mice depends in part on how quickly bacteria-fighting T cells can get to the lungs. According to a new study that will appear online on June 14th in the Journal of Experimental Medicine, another group of T cells delays their arrival.

Previous research has shown that ridding the body of the hindering T cells -- known as regulatory T cells -- enhances the body's ability to fight off TB-causing bacteria. But exactly when and where regulatory T cells act was uncertain. The new study shows that these cells are activated at the same time and place as their bacteria-fighting "effector" cell counterparts.

In response to infection, both populations expand in the lymph nodes that drain the lung. As a result, fewer effector T cells become activated and are dispatched to the lungs to fight the bug.

Others have shown that the most deadly strains of TB generate the most regulatory T cells, suggesting that this may be a tactic used by the bacteria to sidestep immune attack.

Whether clinicians can devise a strategy to interfere with these troublesome cells in humans remains to be seen.


Story Source:

The above post is reprinted from materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shahin Shafiani, Glady%u2019s Tucker-Heard, Ai Kariyone, Kiyoshi Takatsu and Kevin B. Urdahl. Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. Journal of Experimental Medicine, 2010; DOI: 10.1084/jem.20091885

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Rockefeller University Press. "Delayed arrival of TB-fighting T cells." ScienceDaily. ScienceDaily, 14 June 2010. <www.sciencedaily.com/releases/2010/06/100614121554.htm>.
Rockefeller University Press. (2010, June 14). Delayed arrival of TB-fighting T cells. ScienceDaily. Retrieved July 31, 2015 from www.sciencedaily.com/releases/2010/06/100614121554.htm
Rockefeller University Press. "Delayed arrival of TB-fighting T cells." ScienceDaily. www.sciencedaily.com/releases/2010/06/100614121554.htm (accessed July 31, 2015).

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