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Antagonizing atherosclerosis

Date:
July 6, 2010
Source:
Rockefeller University Press
Summary:
Antibody-producing B cells promote atherosclerosis in mice, according to a new study. These findings came as a surprise, as prior studies had suggested that B cells help protect against the disease.

Antibody-producing B cells promote atherosclerosis in mice, according to a study to be published online on July 5th in the Journal of Experimental Medicine. These findings came as a surprise, as prior studies had suggested that B cells help protect against the disease.

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An international team of researchers, led by Ziad Mallat of the Paris Cardiovascular Research Center and the Division of Cardiovascular Medicine at the University of Cambridge, found that getting rid of B cells protected against atherosclerosis in mice. The protective effect was attributed to the increased production of an immune protein called interleukin-17, which was previously shown to hamper atherosclerosis in mice.

Additional work is needed to understand how interleukin-17 interferes with the development of atherosclerotic lesions.

These findings raise the possibility that B cell-depleting drugs, currently used to treat patients with inflammatory disorders like rheumatoid arthritis, may also reduce their risk of atherosclerosis.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ait-Oufella, H., et al. B cell depletion reduces the development of atherosclerosis in mice. Journal of Experimental Medicine, 2010; DOI: 10.1084/jem.20100155

Cite This Page:

Rockefeller University Press. "Antagonizing atherosclerosis." ScienceDaily. ScienceDaily, 6 July 2010. <www.sciencedaily.com/releases/2010/07/100705125332.htm>.
Rockefeller University Press. (2010, July 6). Antagonizing atherosclerosis. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/07/100705125332.htm
Rockefeller University Press. "Antagonizing atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2010/07/100705125332.htm (accessed October 25, 2014).

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