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Antagonizing atherosclerosis

Date:
July 6, 2010
Source:
Rockefeller University Press
Summary:
Antibody-producing B cells promote atherosclerosis in mice, according to a new study. These findings came as a surprise, as prior studies had suggested that B cells help protect against the disease.

Antibody-producing B cells promote atherosclerosis in mice, according to a study to be published online on July 5th in the Journal of Experimental Medicine. These findings came as a surprise, as prior studies had suggested that B cells help protect against the disease.

An international team of researchers, led by Ziad Mallat of the Paris Cardiovascular Research Center and the Division of Cardiovascular Medicine at the University of Cambridge, found that getting rid of B cells protected against atherosclerosis in mice. The protective effect was attributed to the increased production of an immune protein called interleukin-17, which was previously shown to hamper atherosclerosis in mice.

Additional work is needed to understand how interleukin-17 interferes with the development of atherosclerotic lesions.

These findings raise the possibility that B cell-depleting drugs, currently used to treat patients with inflammatory disorders like rheumatoid arthritis, may also reduce their risk of atherosclerosis.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ait-Oufella, H., et al. B cell depletion reduces the development of atherosclerosis in mice. Journal of Experimental Medicine, 2010; DOI: 10.1084/jem.20100155

Cite This Page:

Rockefeller University Press. "Antagonizing atherosclerosis." ScienceDaily. ScienceDaily, 6 July 2010. <www.sciencedaily.com/releases/2010/07/100705125332.htm>.
Rockefeller University Press. (2010, July 6). Antagonizing atherosclerosis. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2010/07/100705125332.htm
Rockefeller University Press. "Antagonizing atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2010/07/100705125332.htm (accessed September 22, 2014).

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