Featured Research

from universities, journals, and other organizations

Protein identified which helps cancer cells to survive stressful conditions

Date:
July 12, 2010
Source:
Public Library of Science
Summary:
Researchers have made a discovery that could lead to the development of more effective treatments for a number of diseases. They have shown that a protein produced when cells are stressed interacts with a stress sensor allowing cells to survive conditions of intense stress. Understanding this interaction may help scientists interfere with cancer cells so the cells can no longer survive exposure to stressful conditions.

Researchers at NUI Galway have made a discovery that could lead to the development of more effective treatments for a number of diseases. They have shown that a protein produced when cells are stressed interacts with a stress sensor allowing cells to survive conditions of intense stress. Understanding this interaction may help scientists interfere with cancer cells so the cells can no longer survive exposure to stressful conditions.

Related Articles


These findings are published in the online, open access journal PLoS Biology.

Healthy cells are not usually under stress, but unhealthy cells, such as cancer cells, are often under considerable stress because they grow rapidly in places where they are not supposed to grow. When a cell is under these stressful conditions, the stress protein Hsp70 is activated to help the cell.

Professor Afshin Samali, lead author of the study and head of the Department of Biochemistry at NUI Galway, and his team have discovered that under cell stress conditions Hsp70 interacts with a receptor in the cell, activating survival mechanisms and preventing apoptosis, the normal cell death mechanism. By understanding more about Hsp70 and the way it functions, scientists can learn how to block its function, allowing unhealthy cells to succumb to stress and die. This could have significant implications in the development of new cancer drugs, which would block the protein to encourage tumor cell death. In contrast to diseases where cell death is abundant such as Alzheimer's, Parkinson's Disease, and Diabetes, increasing the levels of Hsp70 could potentially be used to help these cells survive stressful conditions.

Professor Samali states: "Our results have identified a novel protein-protein interaction that helps cancer cells to survive stressful growth conditions. By interfering with this interaction we hope to develop a new class of anticancer drugs. This work was funded by Science Foundation Ireland and will have a significant impact on cancer research and drug design."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, et al. HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1a-XBP1 Signaling through a Physical Interaction. PLoS Biol, 2010; 8 (7): e1000410 DOI: 10.1371/journal.pbio.1000410

Cite This Page:

Public Library of Science. "Protein identified which helps cancer cells to survive stressful conditions." ScienceDaily. ScienceDaily, 12 July 2010. <www.sciencedaily.com/releases/2010/07/100706171117.htm>.
Public Library of Science. (2010, July 12). Protein identified which helps cancer cells to survive stressful conditions. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/07/100706171117.htm
Public Library of Science. "Protein identified which helps cancer cells to survive stressful conditions." ScienceDaily. www.sciencedaily.com/releases/2010/07/100706171117.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins