Featured Research

from universities, journals, and other organizations

Gene responsible for population disparity in kidney failure, study finds

Date:
July 19, 2010
Source:
Springer Science+Business Media
Summary:
Chronic kidney disease affects millions in North America, with persons of African heritage being at a four-fold higher risk and those of Hispanic heritage having a two-fold higher risk compared to the rest of the population. An international study points to the APOL1 gene as involved in the increased risk of kidney disease in this high-risk population.

Chronic kidney disease affects millions in North America, with persons of African heritage being at a four-fold higher risk and those of Hispanic heritage having a two-fold higher risk compared to the rest of the population. An international study carried out by Dr. Karl Skorecki, from the Technion-Israel Institute of Technology and Rambam Medical Center in Haifa, and his team points to the APOL1 gene as involved in the increased risk of kidney disease in this high-risk population.

The results are to be published online in Springer's journal Human Genetics.

Excitement has been growing in the scientific community worldwide, with an intense race to determine the genetic link responsible for the greatly increased risk many people of African heritage face for end stage kidney disease and the need for dialysis or transplantation. Identifying the correct gene that puts people at risk for progressive kidney disease is necessary to understand the underlying reason for the increased risk, and to be able to find strategies to prevent or slow down kidney failure.

Research studies in the past two years have focused on a particular gene, called MYH9, as being responsible for these population disparities, but no mutations could be identified which might account for the connection.

This led the authors of the study to look beyond MYH9, by computerized data mining of the recently released 1000 Genomes Project dataset. This data mining, combined with the results obtained from DNA analysis in 955 African Americans and Hispanic Americans and 676 individuals from twelve populations residing in Africa, led the authors to specific genetic variations in the neighboring APOL1 gene as responsible for the greatly increased risk for kidney disease in persons of western African heritage.

A key element in identifying mutations in the APOL1 gene associated with kidney failure was the absence of these mutations in the 306 Ethiopian individuals included in the DNA analysis. Several of the authors of the study had already reported that Ethiopians are actually relatively protected from kidney disease and correspondingly do not have the mutations identified as associated with risk for kidney failure.

The authors conclude: "In addition to accounting for the risk previously attributed to MYH9 in persons of African heritage, these findings now set the stage for a new area of research relating the APOL family of genes to kidney disease more generally, and for discovery of numerous additional less frequent mutations in the APOL genes that might also perturb or modify kidney function in many population groups. The challenge in future studies will be to broaden the epidemiological, biological and medical relationship between variation in the APOL1 gene and the risk for an extended spectrum of kidney disease."


Story Source:

The above story is based on materials provided by Springer Science+Business Media. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tzur S et al. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Human Genetics, 2010; DOI: 10.1007/s00439-010-0861-0

Cite This Page:

Springer Science+Business Media. "Gene responsible for population disparity in kidney failure, study finds." ScienceDaily. ScienceDaily, 19 July 2010. <www.sciencedaily.com/releases/2010/07/100715091658.htm>.
Springer Science+Business Media. (2010, July 19). Gene responsible for population disparity in kidney failure, study finds. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2010/07/100715091658.htm
Springer Science+Business Media. "Gene responsible for population disparity in kidney failure, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/07/100715091658.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins