Featured Research

from universities, journals, and other organizations

Researchers find way to make cancer cells more mortal

Date:
July 18, 2010
Source:
Washington State University
Summary:
Researchers have discovered a way to help cancer cells age and die, creating a promising avenue for slowing and even stopping the growth of tumors.

Washington State University researchers have discovered a way to help cancer cells age and die, creating a promising avenue for slowing and even stopping the growth of tumors.

Related Articles


"Hopefully, we can make cancer cells die like normal cells," says Weihang Chai, an assistant professor in the WSU School of Molecular Biosciences and WWAMI medical education program in Spokane. "Basically, you make the cancer cell go from immortal to mortal."

Normal cells lose a little bit of their DNA every time they reproduce as the molecule's strands lose part of their protective tips, called telomeres. Eventually, the telomeres become too short, signaling to the cell to stop replicating and growing.

But cancer cells have a mechanism to keep their DNA strands from shortening, giving them a near eternal life. This is because the enzyme telomerase extends one strand of the cancer cell's DNA while other proteins help extend the second strand.

Chai and her colleagues, writing in the current issue of The EMBO Journal, say they have found a regulatory protein that controls the production of that second strand. They have also found a protein required to synthesize it.

If that second strand of DNA cannot be lengthened, says Chai, it behaves like a normal cell and dies a normal death. She says her team will now focus on developing a strategy to block the regulatory protein's function.

Chai's work is funded by the National Institutes of Health, the American Cancer Society and Washington State.


Story Source:

The above story is based on materials provided by Washington State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xueyu Dai, Chenhui Huang, Amruta Bhusari, Shilpa Sampathi, Kathryn Schubert, Weihang Chai. Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection. The EMBO Journal, 16 July 2010 DOI: 10.1038/emboj.2010.156

Cite This Page:

Washington State University. "Researchers find way to make cancer cells more mortal." ScienceDaily. ScienceDaily, 18 July 2010. <www.sciencedaily.com/releases/2010/07/100716125637.htm>.
Washington State University. (2010, July 18). Researchers find way to make cancer cells more mortal. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/07/100716125637.htm
Washington State University. "Researchers find way to make cancer cells more mortal." ScienceDaily. www.sciencedaily.com/releases/2010/07/100716125637.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins